☆ 4.6 Article

Tumor-associated macrophages improve hypoxia-induced endoplasmic reticulum stress response in colorectal cancer cells by regulating TGF-β1/SOX4

CELLULAR SIGNALLING (2022)

Related references

Note: Only part of the references are listed.

Article Oncology

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

Khiyam Hussain et al.

Summary: Hypoxia in the tumor microenvironment can upregulate the expression of Fc gamma RIIb receptors on tumor-associated macrophages (TAMs), which leads to reduced antibody dependent cellular phagocytosis (ADCP) and decreased efficacy of monoclonal antibody (mAb) immunotherapy. This finding provides a mechanistic basis for targeting Fc gamma RIIb expression or blocking it as a promising strategy for enhancing mAb immunotherapies.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Neurosciences

Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype

Yuyang Liu et al.

Summary: PGCCs promote malignancy and immune-suppressive microenvironment in GBM. PGCCs or their progeny cells may be a potential therapeutic target for GBM.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

Add to Collection

Article Cell Biology

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-? signaling in regulatory T cells

Jian Gu et al.

Summary: The lactate in tumor microenvironment plays a crucial role in regulating Treg cells. It can improve Treg cell stability and function, while its degradation reduces Treg cell induction. Lactate modulates Treg cell generation through lactylation of MOESIN, leading to enhanced interaction with TGF-β receptor I and downstream SMAD3 signaling. Combining lactate dehydrogenase inhibitor with anti-PD-1 treatment shows stronger antitumor effects. MOESIN lactylation levels in Treg cells are associated with the response to anti-PD-1 treatment in hepatocellular carcinoma patients.

CELL REPORTS (2022)

Add to Collection

Review Oncology

Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment

Iljin Kim et al.

Summary: Cancers have regions of low oxygen concentration that activate hypoxia-related signaling pathways. Fibroblasts, one of the most abundant cellular components in the tumor stroma, are significantly affected by oxygen deprivation. This article summarizes the molecular and cellular mechanisms that regulate fibroblasts under hypoxic conditions and their impact on cancer development and progression. It also discusses potential therapeutic strategies targeting fibroblasts in the hypoxic tumor microenvironment.

CANCERS (2022)

Add to Collection

Review Medicine, Research & Experimental

Monocytes in the Tumor Microenvironment

Stefano Ugel et al.

Summary: The review summarizes the current knowledge of the ontogeny, heterogeneity, and functions of monocytes and monocyte-derived cells in cancer, emphasizing the main pathways important for modeling the immunosuppressive tumor microenvironment.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Add to Collection

Review Oncology

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

Bin Wang et al.

Summary: Hypoxic tumor microenvironment (TME) may be a major barrier limiting the efficacy of immunotherapy, through inducing immune suppression and resistance. Targeting hypoxia could enhance the efficacy of immunotherapy and provide a promising combinational therapeutic strategy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites

Fumitoshi Irie et al.

Summary: The extracellular matrix (ECM) and its component hyaluronan (HA) play crucial roles in tumor cell invasion and migration dynamics. TMEM2 is identified as a key player in HA degradation and cell-substrate adhesion, shedding light on the mechanisms of cell migration in an HA-rich environment.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ZFAS1 Promotes Colorectal Cancer Metastasis Through Modulating miR-34b/SOX4 Targeting

Hong Deng et al.

Summary: ZFAS1 has high expression in CRC and is associated with p53, miR-34b, and SOX4. Silencing ZFAS1 can inhibit migration and invasion ability of CRC cells by modulating the EMT process, with miR-34b directly targeting ZFAS1 and SOX4 being a downstream target of miR-34b.

CELL BIOCHEMISTRY AND BIOPHYSICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes

Zhentong Shen et al.

Summary: This study reveals that FTO reduces adipocyte apoptosis by activating the JAK2/STAT3 signaling pathway and inhibiting UPRmt, suggesting a novel mechanism for the treatment of obesity and related metabolic syndromes.

APOPTOSIS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Oncology

CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion

Gurcan Gunaydin

Summary: CAFs and TAMs are crucial players in the tumor microenvironment, playing key roles in tumor growth and progression. They have intricate interactions with each other and with tumor cells, impacting tumor progression and immune evasion. Understanding these interactions may lead to the development of novel therapeutic targets for cancer.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Review Cell Biology

Endoplasmic Reticulum Stress and Tumor Microenvironment in Bladder Cancer: The Missing Link

Zhenyu Nie et al.

Summary: Bladder cancer is a common malignant tumor of the urinary system, and research related to tumor microenvironment and endoplasmic reticulum stress is crucial for improving treatment outcomes. The challenge lies in overcoming therapeutic resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Rashi Singhal et al.

Summary: This study reveals the essential role of HIF-2α in colorectal cancer (CRC) progression, demonstrating its regulation of cell death via modulation of cellular iron and oxidation. Inhibitors targeting HIF-2α can enhance cancer cells' susceptibility to oxidative cell death.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Review Oncology

SOX4: Epigenetic regulation and role in tumorigenesis

Hamza Hanieh et al.

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Cell Biology

miR-140-5p is negatively correlated with proliferation, invasion, and tumorigenesis in malignant melanoma by targeting SOX4 via the Wnt/β-catenin and NF-κB cascades

Ge Zhao et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Review Oncology

SOX4: The unappreciated oncogene

Carlos S. Moreno

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Pathology

ASIP OUTSTANDING INVESTIGATOR AWARD LECTURE Endoplasmic Reticulum Stress Signaling in Cancer Cells

Scott A. Oakes

AMERICAN JOURNAL OF PATHOLOGY (2020)

Add to Collection

Article Oncology

Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer

Dening Ma et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Xiaoxiang Chen et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer

Lina Qi et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Review Oncology

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

Entaz Bahar et al.

CANCERS (2019)

Add to Collection

Review Oncology

Crosstalk between cancer and immune cells: Role of tumor-associated macrophages in the tumor microenvironment

Jing Wang et al.

CANCER MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER

Robert Thomas Schinzel et al.

CELL (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment

Yoshiro Itatani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

SOX4 can redirect TGF-beta-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis

Stephin J. Vervoort et al.

NUCLEIC ACIDS RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

TGF-beta downregulation-induced cancer cell death is finely regulated by the SAPK signaling cascade

Zhezhu Han et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer

Ines Marmol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Review Chemistry, Multidisciplinary

Exploiting the cancer niche: Tumor-associated macrophages and hypoxia as promising synergistic targets for nano-based therapy

Vera L. Silva et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Meeting Abstract Oncology

Bladder cancer GWAS signal at 4p16.3 affects response of TMEM129 to chemically induced endoplasmic reticulum stress

A. Rouf Banday et al.

CANCER RESEARCH (2016)

Add to Collection

Article Oncology

TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer

Hyeseung Lee et al.

CANCER RESEARCH (2016)

Add to Collection

Article Oncology

TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling

Isamu Sakabe et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Add to Collection

Article Medicine, General & Internal

Colorectal cancer

Ernst J. Kuipers et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Add to Collection

Article Endocrinology & Metabolism

ERG-SOX4 interaction promotes epithelial-mesenchymal transition in prostate cancer cells

Lin Wang et al.

PROSTATE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma

J. Tang et al.

CELL DEATH AND DIFFERENTIATION (2012)

Add to Collection

Article Gastroenterology & Hepatology

Role of TGF-β1, its receptor TGFβRII, and Smad proteins in the progression of colorectal cancer

Maya Gulubova et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2010)

Add to Collection

Article Gastroenterology & Hepatology

Endoplasmic Reticulum Stress and the Unfolded Protein Response

Ashwani Kapoor et al.

CLINICS IN LIVER DISEASE (2009)

Add to Collection

Article Pathology

Relations of TGF-1 with HIF-1, GLUT-1 and longer survival of colorectal cancer patients

Mariola Sulkowska et al.

PATHOLOGY (2009)

Add to Collection

Article Oncology

Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status

A. Andersson et al.

LEUKEMIA (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Endoplasmic reticulum stress and apoptosis

Jitka Faitova et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2006)

Add to Collection

Article Oncology

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

LX Sun et al.

CANCER CELL (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression

P Hu et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Add to Collection

Article Oncology

Novel genes associated with malignant melanoma but not benign melanocytic lesions

D Talantov et al.

CLINICAL CANCER RESEARCH (2005)

Add to Collection

Article Oncology

Differential expression of SOX4 and SOX11 in medulloblastoma

CJ Lee et al.

JOURNAL OF NEURO-ONCOLOGY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.