Breaking down a gut-to-brain circuit that prevents malabsorption

The ileal brake is an important reflex that ensures proper absorption of nutrients. This involves intestinal GLP-1 release, which recruits an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted to treat obesity and gastrointestinal dysfunction.

Automated summary

The ileal brake is an important reflex involving the release of intestinal GLP-1, which activates an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted for the treatment of obesity and gastrointestinal dysfunction.