Invasive glioma cells: The malignant pioneers that follow the current

Article Multidisciplinary Sciences

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

Pengxiang Chen et al.

Summary: Animals receive sensory stimuli from the environment, which are essential for survival but can also impact physiological status and disease development. This study demonstrates that olfaction directly regulates the development of malignant glioma through olfactory neuronal circuits.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Glioma progression is shaped by genetic evolution and microenvironment interactions

Frederick S. Varn et al.

Summary: This study analyzed RNA and DNA sequencing data from tumor pairs of patients with IDH-wild-type and IDH-mutant glioma, and identified the factors driving therapy resistance and recurrence. The results showed that IDH status, histological features, somatic alterations, and microenvironment interactions play important roles in glioma recurrence. Furthermore, specific cellular and genetic changes were associated with tumor growth, invasion, and neuronal interactions, providing potential targets for altering disease progression.

CELL (2022)

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Article Biochemistry & Molecular Biology

Glioblastoma hijacks neuronal mechanisms for brain invasion

Varun Venkataramani et al.

Summary: A subpopulation of glioblastoma cells lacking connections with other tumor cells and astrocytes but receiving synaptic input from neurons drives whole-brain colonization. These cells resemble neuronal and neural-progenitor-like states and invade the brain using mechanisms similar to neuronal migration. Neuronal activity induces calcium signals, leading to the formation of tumor microtubes and increased invasion speed. This study reveals how neuronal mechanisms govern glioblastoma cell invasion and explains the close interlink between tumor dissemination and cellular heterogeneity.

CELL (2022)

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Article Multidisciplinary Sciences

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

Yuan Pan et al.

Summary: Neurons play an essential role in promoting the growth of certain types of brain tumors, such as optic pathway gliomas driven by mutations in the NF1 tumor suppressor gene. Inhibition of neuronal activity through light deprivation can prevent tumor formation and progression, highlighting a potential therapeutic strategy and the importance of Nf1 mutation-mediated dysregulation of neuronal signaling pathways in cancer predisposition syndromes.

NATURE (2021)

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Article Biochemistry & Molecular Biology