APOE told me put my fat in the bag and nobody gets hurt

The epsilon 4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer's disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report APOE-driven cell-type-specific changes that may contribute to Alzheimer's disease risk.

Automated summary

In this study, the researchers demonstrate APOE-driven cell-type-specific changes that may contribute to the increased risk of Alzheimer's disease.