New antivirals exploit viral feedback tricks for a cure without resistance

Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.

Automated summary

The researchers propose a new type of antiviral drugs that efficiently cure infected cells and minimize the chance of resistance.