Journal
CANCER RESEARCH
Volume 82, Issue 15, Pages 2674-2677Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-21-2978
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Funding
- NIH [P30CA016520, U24CA224122]
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In recent years, there has been a growing recognition that P values are often misused or misinterpreted in biomedical research, especially with the emergence of big health data. To address this problem, sound study design and appropriate statistical analysis strategies are needed.
In recent years, there has been a growing recognition that P values, albeit useful in reporting data analysis results, have often been misused or misinterpreted in biomedical research. The emergence of big health data such as genomics data and electronic health records, sometimes combined with inadequate experimental design, has exacerbated this problem, which has become a major cause of the ongoing crisis in reproducibility in biomedical research. We aim to shed light and raise awareness of common misuses and pitfalls of P values and discuss potential mitigation strategies that leverage state-of-the-art statistical methods. The best practices always start with a sound study design including a robust data collection strategy to minimize data bias and a carefully thought-out analysis plan that can address potential misuses and pitfalls of P values. We highly encourage biomedical researchers to engage and involve statis-ticians from the very beginning of their studies.
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