Journal
CANCER CELL INTERNATIONAL
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12935-022-02619-6
Keywords
NFATc4; Cancer; Proliferation; Invasion; Migration; Prognosis; Drug resistance
Categories
Funding
- National Natural Science Foundation of China [31771582, 31271445]
- Guangdong Natural Science Foundation of China [2017A030313131]
- Thousand, Hundred, and Ten Project of the Department of Education of Guangdong Province of China
- Basic and Applied Research Major Projects of Guangdong Province of China [2017KZDXM035, 2018KZDXM036]
- Yang FanProject of Guangdong Province of China
- Shantou Medical Health Science and Technology Plan [200624165260857]
Ask authors/readers for more resources
NFATc4, a transcription factor, plays a crucial role in various cancers. It is involved in the initiation and progression of cancer, making it a potential molecular therapeutic target.
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breast, ovary, cervix, skin, liver, pancreas, as well as glioma, primary myelofibrosis and acute myelocytic leukemia). In this review, we cover the latest knowledge on NFATc4 expression pattern, post-translational modification, epigenetic regulation, transcriptional activity regulation and its downstream targets. Furthermore, we perform database analysis to reveal the prognostic value of NFATc4 in various cancers and discuss the current unexplored areas of NFATc4 research. All in all, the result from these studies strongly suggest that NFATc4 has the potential as a molecular therapeutic target in multiple human cancer types.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
