Metastasis

Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy, and how they interact with their new microenvironment. We asked experts to discuss some of the unknowns, advances, and areas of opportunity related to cancer metastasis.

Automated summary

This article discusses some of the unknown areas, advances, and opportunities related to cancer metastasis, including the reasons for tumor cells remaining dormant for years, the resistance mechanisms against the immune system and systemic therapy, and their interaction with the new microenvironment.