Training the host organism to enhance anti-cancer immunity

Article Gastroenterology & Hepatology

Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial

Christina M. Brennan et al.

Summary: This study assessed the effect of famotidine on inflammation and symptomatic recovery in patients with mild to moderate COVID-19. The results showed that famotidine led to earlier resolution of symptoms and inflammation without reducing anti-SARS-CoV-2 immunity. Additional randomized trials are needed to confirm these findings.

GUT (2022)

Add to Collection

Article Oncology

Exercise-induced engagement of the IL-15/1L-15Rα axis promotes anti-tumor immunity in pancreatic cancer

Emma Kurz et al.

Summary: Aerobic exercise reduces the growth of pancreatic ductal adenocarcinoma (PDA) by modulating the immune system. It promotes the accumulation of tumor-infiltrating immune cells and enhances the tumor-protective effects. In clinical samples, an increase of anti-tumor immune cells is observed. Targeting the IL-15/IL-15R alpha pathway shows promising results in treatment.

CANCER CELL (2022)

Add to Collection

Review Oncology

Developing dietary interventions as therapy for cancer

Samuel R. Taylor et al.

Summary: This Review discusses metabolic alterations and vulnerabilities in different types of cancer, and suggests using dietary interventions in combination with pharmacologic therapies to target these changes. However, diet studies in cancer patients are rare and lack robust evidence. The article also explores how dietary strategies can be combined with pharmacological therapies in treating cancer.

NATURE REVIEWS CANCER (2022)

Add to Collection

Article Oncology

Exercise Training Improves Tumor Control by Increasing CD8+ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade

Igor L. Gomes-Santos et al.

Summary: Exercise training can delay tumor growth, increase vascular normalization, and enhance CD8(+) T-cell infiltration, playing an important role in breast cancer treatment.

CANCER IMMUNOLOGY RESEARCH (2021)

Add to Collection

Review Multidisciplinary Sciences