4.5 Review

The obesity-breast cancer link: a multidisciplinary perspective

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

Sebastian J. Hofer et al.

Summary: Age-associated diseases are on the rise, leading to a need for efficient and low-cost methods. Caloric restriction (CR) is effective but implementation can be challenging, giving rise to CR-mimicking interventions. The advantages and disadvantages of these dietary interventions in humans must be carefully considered.

EMBO MOLECULAR MEDICINE (2022)

Article Immunology

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

Lydia Dyck et al.

Summary: Obesity suppresses the activity of CD8 T cells in anti-tumor immunity, and this suppression can be partially reversed by weight loss and immunotherapy.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

Review Medicine, General & Internal

Advancements in the Treatment of Triple-Negative Breast Cancer: A Narrative Review of the Literature

Ian Landry et al.

Summary: Triple-negative breast cancers (TNBCs) are aggressive tumors with high recurrence rate and chemoresistance. Current treatment options include chemotherapy, targeted therapy, immune checkpoint inhibitors, and antibody-drug conjugates. Early-stage patients may benefit from chemotherapy, while targeted therapies can be considered for metastatic TNBC patients. Individualized treatment plans should be selected based on tumor stage, mutational burden, and patient conditions.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

Review Nutrition & Dietetics

An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer

Jakub Morze et al.

Summary: This systematic review updated the evidence on the association between adherence to the Mediterranean diet (MedDiet) and cancer mortality, site-specific cancer risk in the general population, all-cause mortality and cancer recurrence among cancer survivors. The analysis included 117 studies with 3,202,496 participants, showing an inverse association between highest adherence to MedDiet and various cancer risks, while moderate certainty of evidence was found for some outcomes.

EUROPEAN JOURNAL OF NUTRITION (2021)

Article Oncology

Neighborhood-Level Redlining and Lending Bias Are Associated with Breast Cancer Mortality in a Large and Diverse Metropolitan Area

Lindsay J. Collin et al.

Summary: The study revealed that living in redlined areas significantly increases breast cancer mortality, while residing in areas with pronounced lending bias decreases breast cancer mortality. Non-Hispanic Black and Non-Hispanic White women experience different levels of mortality under these influences, highlighting the need for further research.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

Article Oncology

The effect of caloric restriction and fasting on cancer

Mona Alidadi et al.

Summary: Caloric restriction (CR) and fasting have shown potential anticancer effects by reducing tumor progression, enhancing death of cancer cells, and elevating the effectiveness and tolerability of chemo- and radiotherapies. However, clinical studies on the potential of CR and fasting in cancer treatment are scarce and inconsistent, requiring further investigation to clarify their impact.

SEMINARS IN CANCER BIOLOGY (2021)

Article Cell Biology

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Giulia Salvadori et al.

Summary: The study demonstrates that a fasting-mimicking diet activates starvation escape pathways in TNBC cells and reduces stemness markers in CSCs, leading to decreased cell numbers and improved mouse survival. Additionally, the diet activates different survival/growth pathways in differentiated cancer cells, which can be targeted by drugs to promote tumor regression.

CELL METABOLISM (2021)

Review Biochemistry & Molecular Biology

Roles of circadian clocks in cancer pathogenesis and treatment

Yool Lee

Summary: Circadian clocks play a crucial role in optimizing physiological functions and behaviors in response to daily environmental changes, but dysregulation can increase susceptibility to diseases, especially cancer. Recent studies have highlighted the dynamic crosstalk between circadian clocks and cancer pathways, offering new insights into potential therapeutic strategies for cancer treatment.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Article Endocrinology & Metabolism

Effect of time restricted eating on body weight and fasting glucose in participants with obesity: results of a randomized, controlled, virtual clinical trial

Pamela M. Peeke et al.

Summary: The study investigated the effects of combining time restricted eating (TRE) with a commercial weight management program on body weight and fasting blood glucose in individuals with obesity. Results showed significant improvements in weight and fasting blood glucose in the 14:10 TRE group after 8 weeks, indicating the effectiveness of this approach for weight loss and metabolic health.

NUTRITION & DIABETES (2021)

Article Oncology

Association of Obesity With Breast Cancer Outcome in Relation to Cancer Subtypes: A Meta-Analysis

Ana Elisa Lohmann et al.

Summary: Obesity was associated with slightly worse DFS and OS in all BC subtypes. Overweight was not associated with DFS or OS in HER2+ BC and TNBC, but was associated with worse OS in HR+HER2- BC.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Oncology

Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

Lauren E. Hillers-Ziemer et al.

Summary: Obesity promotes rapid growth and metastases of mammary tumors in mice by increasing recruitment of myeloid lineage cells and deposition of collagen fibers within the lungs. Lung stromal cells isolated from obese mice show higher expression of extracellular matrix proteins and inflammatory cytokines, facilitating metastatic growth prior to tumor formation. Understanding these mechanisms may provide new therapeutic options for obese breast cancer patients.

CANCERS (2021)

Review Oncology

Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy

Erwan Eriau et al.

Summary: Reduced food intake and caloric restriction mimetics have been shown to increase healthy lifespan, reduce cancer incidence, and enhance responses to certain cancer treatments. These effects are mediated by cellular mechanisms and vary between cancer cells and healthy cells due to differences in metabolic requirements. Additionally, both reduced food intake and caloric restriction mimetics can induce autophagy, improving the efficacy of certain cancer treatments that induce immunogenic cell death and enhance the therapeutic efficacy of chemo-immunotherapies.

CANCERS (2021)

Article Nutrition & Dietetics

Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer

Fokhrul Hossain et al.

Summary: The study investigates how obesity modulates the gut microbiome in a TNBC mouse model, finding that obesity decreases alpha diversity. Obesity was the only significant factor explaining the similarity of bacterial communities. In functional profile analysis, obesity, tumor presence, and obesity-tumor interaction were significant in explaining variation, with obesity having the strongest correlation.

NUTRIENTS (2021)

Review Oncology

Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer

Maret L. Maliniak et al.

Summary: Obesity is a known risk factor for postmenopausal breast cancer, especially hormone receptor-positive breast cancers, and is associated with poorer prognosis. Crown-like structures in breast adipose tissue (CLS-B) have been identified as a marker of local inflammation, with evidence linking their presence to metabolic and inflammatory factors contributing to breast cancer development and progression. However, further research is needed to determine the clinical utility of CLS-B as a marker for breast cancer risk or prognosis.

CANCERS (2021)

Article Oncology

The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data

Natansh D. Modi et al.

Summary: The study found that higher BMI was associated with worse survival in early breast cancer patients, but paradoxically, it was associated with improved survival in advanced breast cancer patients.

NPJ BREAST CANCER (2021)

Review Medicine, General & Internal

Association of Obesity With Survival Outcomes in Patients With Cancer A Systematic Review and Meta-analysis

Fausto Petrelli et al.

Summary: Obesity is associated with increased mortality in cancer patients overall, but patients with obesity and certain types of cancer such as lung cancer, renal cell carcinoma, and melanoma may have better survival outcomes compared to non-obese patients with the same cancers. Weight-reducing strategies could potentially help reduce mortality in these patients.

JAMA NETWORK OPEN (2021)

Review Nutrition & Dietetics

Time-restricted feeding regulates molecular mechanisms with involvement of circadian rhythm to prevent metabolic diseases

Falak Zeb et al.

Summary: Time-restricted feeding (TRF) regulates the circadian rhythm of food intake to prevent metabolic diseases, optimize nutrient utilization, and coordinate circadian clock components and nutrient-sensing pathways to protect metabolic health.

NUTRITION (2021)

Review Nutrition & Dietetics

Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis

Lucilla Crudele et al.

Summary: The prevalence of overweight and obesity has increased dramatically worldwide in recent years, leading to a higher risk of chronic diseases such as cancer. Strategies focused on limiting fat accumulation and lifestyle interventions are crucial to prevent cancer and reduce excess body weight.

NUTRIENTS (2021)

Review Oncology

Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer

Chongru Zhao et al.

Summary: Obesity is closely linked to breast cancer and can significantly impact the development and treatment of breast cancer.

FRONTIERS IN ONCOLOGY (2021)

Article Endocrinology & Metabolism

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Heidi H. Pak et al.

Summary: The study demonstrates that prolonged fasting plays a crucial role in the effects of calorie restriction on insulin sensitivity, fuel utilization, and aging in mice. Simply reducing caloric intake alone is not enough to replicate all these effects, highlighting the importance of daily prolonged fasting in regulating metabolic health and longevity.

NATURE METABOLISM (2021)

Review Oncology

Energy and caloric restriction, and fasting and cancer: a narrative review

Ezzeldin M. Ibrahim et al.

Summary: Dietary interventions have a significant impact on body metabolism and can hinder cancer growth and progression while enhancing the efficacy of chemotherapy and radiation therapy. Although current clinical trials have small sample sizes, they have shown clinical benefits for cancer patients.

SUPPORTIVE CARE IN CANCER (2021)

Article Nutrition & Dietetics

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

James L. Dorling et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2020)

Article Oncology

Obesity-associated methylation in breast tumors: a possible link to disparate outcomes?

Whitney L. Do et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Article Multidisciplinary Sciences

Re-definition of claudin-low as a breast cancer phenotype

Christian Fougner et al.

NATURE COMMUNICATIONS (2020)

Review Multidisciplinary Sciences

Dietary modifications for enhanced cancer therapy

Naama Kanarek et al.

NATURE (2020)

Article Oncology

Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study

Giuseppe Buono et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Article Multidisciplinary Sciences

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Irene Caffa et al.

NATURE (2020)

Article Oncology

Obesity diminishes response to PD-1-based immunotherapies in renal cancer

Shannon K. Boi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Public, Environmental & Occupational Health

Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors

Om Prakash et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Article Public, Environmental & Occupational Health

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Xiang Shu et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

Review Oncology

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

Kyuwan Lee et al.

CURRENT ONCOLOGY REPORTS (2019)

Review Oncology

Effects of short-term fasting on cancer treatment

Stefanie de Groot et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Immunology

Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

Payal Tiwari et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Biochemistry & Molecular Biology

Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression

Priya Bhardwaj et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Review Oncology

The Many Faces of Obesity and Its Influence on Breast Cancer Risk

Tanya Agurs-Collins et al.

FRONTIERS IN ONCOLOGY (2019)

Article Oncology

4T1 Mammary Carcinoma Colonization of Metastatic Niches Is Accelerated by Obesity

Gabriela Coeli Menezes Evangelista et al.

FRONTIERS IN ONCOLOGY (2019)

Article Cell Biology

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

Jose M. Bravo-San Pedro et al.

CELL METABOLISM (2019)

Review Nutrition & Dietetics

Cancer and Mediterranean Diet: A Review

Maria Chiara Mentella et al.

NUTRIENTS (2019)

Article Surgery

Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort

Daniel P. Schauer et al.

ANNALS OF SURGERY (2019)

Article Endocrinology & Metabolism

The Role of Adipokines in Breast Cancer: Current Evidence and Perspectives

Gerasimos Socrates Christodoulatos et al.

CURRENT OBESITY REPORTS (2019)

Editorial Material Immunology

The complicated effects of obesity on cancer and immunotherapy

Ziming Wang et al.

IMMUNOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Ziming Wang et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland

Iliana Tenvooren et al.

ONCOGENE (2019)

Review Medicine, General & Internal

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Oncology

Differences in Breast Cancer Survival by Molecular Subtypes in the United States

Nadia Howlader et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2018)

Review Immunology

Myeloid derived-suppressor cells: their role in cancer and obesity

Suzanne Strand-Rosenberg

CURRENT OPINION IN IMMUNOLOGY (2018)

Article Immunology

Impaired natural killer cell subset phenotypes in human obesity

Ina Baehr et al.

IMMUNOLOGIC RESEARCH (2018)

Review Cell Biology

The autophagic network and cancer

Marissa D. Rybstein et al.

NATURE CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells

Zunyue Zhang et al.

ONCOGENE (2018)

Review Biochemistry & Molecular Biology

Adipocyte biology in breast cancer: From silent bystander to active facilitator

Junjeong Choi et al.

PROGRESS IN LIPID RESEARCH (2018)

Review Oncology

Challenges and perspectives in the treatment of diabetes associated breast cancer

Samson Mathews Samuel et al.

CANCER TREATMENT REVIEWS (2018)

Review Oncology

Fasting and cancer: molecular mechanisms and clinical application

Alessio Nencioni et al.

NATURE REVIEWS CANCER (2018)

Article Oncology

Obesity promotes the expansion of metastasis-initiating cells in breast cancer

Melanie Bousquenaud et al.

BREAST CANCER RESEARCH (2018)

Article Oncology

Recurrence dynamics of breast cancer according to baseline body mass index

Elia Biganzoli et al.

EUROPEAN JOURNAL OF CANCER (2017)

Article Medicine, General & Internal

Molecular alterations in triple-negative breast cancer-the road to new treatment strategies

Carsten Denkert et al.

LANCET (2017)

Review Medicine, General & Internal

Breast cancer

Nadia Harbeck et al.

LANCET (2017)

Article Medicine, General & Internal

HER2-positive breast cancer

Sibylle Loibl et al.

LANCET (2017)

Review Endocrinology & Metabolism

Adapting to obesity with adipose tissue inflammation

Shannon M. Reilly et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Review Endocrinology & Metabolism

The cellular and molecular bases of leptin and ghrelin resistance in obesity

Huxing Cui et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Review Endocrinology & Metabolism

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

Claire L. Donohoe et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Article Multidisciplinary Sciences

Caloric restriction improves health and survival of rhesus monkeys

Julie A. Mattison et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

Triple-negative breast cancer and its association with obesity (Review)

Heng Sun et al.

MOLECULAR AND CLINICAL ONCOLOGY (2017)

Review Cell Biology

Calorie restriction in humans: An update

Jasper Most et al.

AGEING RESEARCH REVIEWS (2017)

Review Oncology

Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review

Caroline Himbert et al.

CANCER PREVENTION RESEARCH (2017)

Article Medicine, Research & Experimental

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells

Yuan Yuan Wang et al.

JCI INSIGHT (2017)

Article Oncology

Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer

Neil M. Iyengar et al.

CLINICAL CANCER RESEARCH (2016)

Review Oncology

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

Shelly Kaushik et al.

CANCER AND METASTASIS REVIEWS (2016)

Article Oncology

Deubiquitination and Stabilization of PD-L1 by CSN5

Seung-Oe Lim et al.

CANCER CELL (2016)

Article Oncology

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Federico Pietrocola et al.

CANCER CELL (2016)

Article Oncology

Association of Locoregional Control With High Body Mass Index in Women Undergoing Breast Conservation Therapy for Early-Stage Breast Cancer

Carmen Bergom et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

Review Oncology

Obesity and Cancer Mechanisms: Cancer Metabolism

Benjamin D. Hopkins et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Review Oncology

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation

Neil M. Iyengar et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Review Immunology

Human CD56bright NK Cells: An Update

Tatiana Michel et al.

JOURNAL OF IMMUNOLOGY (2016)

Article Endocrinology & Metabolism

Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity

Heekyung Chung et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Review Biochemistry & Molecular Biology

Leotin Regulation of Immune Responses

Caitlin Naylor et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Multidisciplinary Sciences

Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis

Rainer J. Klement et al.

PLOS ONE (2016)

Review Oncology

Obesity and cancer: mechanistic insights from transdisciplinary studies

Emma H. Allott et al.

ENDOCRINE-RELATED CANCER (2015)

Article Cell Biology

A novel leptin antagonist peptide inhibits breast cancer growth in vitro and in vivo

Stefania Catalano et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

Review Endocrinology & Metabolism

Weight regaining: From statistics and behaviors to physiology and metabolism

Costas A. Anastasiou et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

Article Endocrinology & Metabolism

Impact of weight bias and stigma on quality of care and outcomes for patients with obesity

S. M. Phelan et al.

OBESITY REVIEWS (2015)

Article Cell Biology

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

Bo Ri Seo et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Pharmacology & Pharmacy

Adipokines in health and disease

Mathias Fasshauer et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Article Oncology

Targeting the Androgen Receptor in Breast Cancer

KeeMing Chia et al.

CURRENT ONCOLOGY REPORTS (2015)

Review Nutrition & Dietetics

Definition of the Mediterranean Diet: A Literature Review

Courtney Davis et al.

NUTRIENTS (2015)

Review Oncology

Cross-talk between adiponectin and IGF-IR in breast cancer

Loredana Mauro et al.

FRONTIERS IN ONCOLOGY (2015)

Article Hematology

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

Tracey McLaughlin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Review Cell Biology

Fasting: Molecular Mechanisms and Clinical Applications

Valter D. Longo et al.

CELL METABOLISM (2014)

Review Immunology

Metabolism of activated T lymphocytes

Jason A. Maciolek et al.

CURRENT OPINION IN IMMUNOLOGY (2014)

Article Immunology

Insulin Inhibits IL-10-Mediated Regulatory T Cell Function: Implications for Obesity

Jonathan M. Han et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Caloric restriction mimetics: towards a molecular definition

Frank Madeo et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Oncology

Toxicity and tolerability of adjuvant breast cancer chemotherapy in obese women

James P. Carroll et al.

MEDICAL ONCOLOGY (2014)

Article Multidisciplinary Sciences

The cellular and molecular origin of tumor-associated macrophages

Ruth A. Franklin et al.

SCIENCE (2014)

Article Oncology

PD-L1 Expression in Triple-Negative Breast Cancer

Elizabeth A. Mittendorf et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Biochemistry & Molecular Biology

Reprogramming of the Circadian Clock by Nutritional Challenge

Kristin L. Eckel-Mahan et al.

Article Cell Biology

Caloric restriction augments radiation efficacy in breast cancer

Anthony D. Saleh et al.

CELL CYCLE (2013)

Review Cell Biology

Fibrosis and Adipose Tissue Dysfunction

Kai Sun et al.

CELL METABOLISM (2013)

Article Oncology

Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

Louise R. Howe et al.

CLINICAL CANCER RESEARCH (2013)

Review Cardiac & Cardiovascular Systems

Caloric Restriction IMPLICATIONS FOR HUMAN CARDIOMETABOLIC HEALTH

Connie W. Bales et al.

JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION (2013)

Review Cell Biology

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

Evi M. Mercken et al.

AGEING RESEARCH REVIEWS (2012)

Article Endocrinology & Metabolism

Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions

Christiane D. Wrann et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Immunology

Immunological complications of obesity

Thirumala-Devi Kanneganti et al.

NATURE IMMUNOLOGY (2012)

Review Oncology

Treatment of HER2-positive breast cancer: current status and future perspectives

Carlos L. Arteaga et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Cell Biology

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

Changhan Lee et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Review Oncology

The immune contexture in human tumours: impact on clinical outcome

Wolf Herman Fridman et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Cancer-associated adipocytes promotes breast tumor radioresistance

Ludivine Bochet et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Oncology

Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study

Rehana L. Ahmed et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

Article Oncology

Caloric restriction reduces growth of mammary tumors and metastases

Mariana S. De Lorenzo et al.

CARCINOGENESIS (2011)

Article Biochemistry & Molecular Biology

Association between life-span extension by caloric restriction and thiol redox state in two different strains of mice

Igor Rebrin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Biochemistry & Molecular Biology

Gr-1+ CD11b+ Myeloid-derived Suppressor Cells Suppress Inflammation and Promote Insulin Sensitivity in Obesity

Sheng Xia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Oncology

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

Marianne Ewertz et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Public, Environmental & Occupational Health

Olive oil, an essential component of the Mediterranean diet, and breast cancer

Eduard Escrich et al.

PUBLIC HEALTH NUTRITION (2011)

Article Multidisciplinary Sciences

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Dalit Barkan et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

Review Immunology

Thymic fatness and approaches to enhance thymopoietic fitness in aging

Vishwa Deep Dixit

CURRENT OPINION IN IMMUNOLOGY (2010)

Article Oncology

Molecular Stratification of Triple-Negative Breast Cancers

Charles M. Perou

ONCOLOGIST (2010)

Article Cell Biology

Fasting and cancer treatment in humans: A case series report

Fernando M. Safdie et al.

AGING-US (2009)

Article Hematology

Obesity accelerates thymic aging

Hyunwon Yang et al.

BLOOD (2009)

Article Oncology

Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition

Laura Baglietto et al.

BREAST CANCER RESEARCH AND TREATMENT (2009)

Editorial Material Medical Laboratory Technology

Understanding Resistance to Tamoxifen in Hormone Receptor-Positive Breast Cancer

Michaela J. Higgins et al.

CLINICAL CHEMISTRY (2009)

Review Immunology

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

Suzanne Ostrand-Rosenberg et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Satoshi Nishimura et al.

NATURE MEDICINE (2009)

Article Endocrinology & Metabolism

Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient?

Lydia A. Lynch et al.

OBESITY (2009)

Review Oncology

Basal-like breast cancer: A critical review

Emad A. Rakha et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Article Biochemistry & Molecular Biology

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

I. Murano et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Multidisciplinary Sciences

Starvation-dependent differential stress resistance protects normal but not cancer COS against high-dose chemotherapy

Lizzia Raffaghello et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Medicine, Research & Experimental

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Carey N. Lumeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Endocrinology & Metabolism

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

Naomi Hosogai et al.

DIABETES (2007)

Article Medicine, General & Internal

Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study

Lisa A. Carey et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

Review Oncology

Distinct role of macrophages in different tumor microenvironments

CE Lewis et al.

CANCER RESEARCH (2006)

Article Medicine, General & Internal

Relation between chemotherapy dose, oestrogen receptor expression, and body-mass index

M Colleoni et al.

LANCET (2005)

Article Medicine, General & Internal

Undertreatment of obese women receiving breast cancer chemotherapy

JJ Griggs et al.

ARCHIVES OF INTERNAL MEDICINE (2005)

Article Oncology

Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer

WD Foulkes et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)

Article Medicine, Research & Experimental

Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)