Journal
JOURNAL OF CLINICAL PHARMACOLOGY
Volume 56, Issue 11, Pages 1387-1394Publisher
WILEY
DOI: 10.1002/jcph.752
Keywords
nintedanib; pharmacokinetics; bioavailability; healthy volunteers; cancer patients
Categories
Funding
- Boehringer Ingelheim
Ask authors/readers for more resources
Nintedanib, a triple angiokinase inhibitor, has undergone clinical investigation for the treatment of solid tumors and idiopathic pulmonary fibrosis. Nintedanib (Vargatef((R))) plus docetaxel is approved in the EU for the treatment of patients with adenocarcinoma non-small cell lung cancer (NSCLC) after first-line chemotherapy, and as monotherapy (Ofev((R))) in the United States and EU for the treatment of patients with idiopathic pulmonary fibrosis. Pharmacokinetics (PK) of nintedanib after oral single and multiple doses and intravenous (IV) administration were assessed using 3 data sets: (1) an absolute bioavailability trial that enrolled 30 healthy volunteers; (2) a pooled data analysis of 4 studies that enrolled a total of 107 healthy volunteers; and (3) a pooled data analysis of 4 studies that enrolled a total of 149 patients with advanced cancer. In the absolute bioavailability trial of healthy volunteers, nintedanib showed a high total clearance (geometric mean 1390 mL/min) and a high volume of distribution at steady state (V-ss=1050L). Urinary excretion of IV nintedanib was about 1% of dose; renal clearance was about 20mL/min and therefore negligible. There was no deviation from dose proportionality after IV administration in the dose range tested. Absolute bioavailability of oral nintedanib (100mg capsule) relative to IV dosing (4-hour infusion, 6mg) was slightly below 5%. Nintedanib was quickly absorbed after oral administration. It underwent rapid and extensive first-pass metabolism and followed at least biphasic disposition kinetics. In advanced cancer patients, steady state was reached at the latest at 7days for twice-daily dosing. Nintedanib's PK was time-independent; accumulation after repeated administration was negligible.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available