Journal
JOURNAL OF CLINICAL PHARMACOLOGY
Volume 57, Issue 2, Pages 219-229Publisher
WILEY
DOI: 10.1002/jcph.796
Keywords
pharmacokinetics; obesity; pediatric; pharmacogenomics; metformin; weight loss
Categories
Funding
- Intramural Research Program of the National Institutes of Health
- Clinical Center Pharmacy Department
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, Program in Developmental Endocrinology and Genetics grant from the NICHD [1ZIAHD000641]
- National Institute forMinority Health and Health Disparities (NIMHD), NIH
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Steady-state population pharmacokinetics of a noncommercial immediate-release metformin (hydrochloride) drug product were characterized in 28 severely obese children with insulin resistance. The concentration-time profiles with double peaks were well described by a 1-compartment model with 2 absorption sites. Mean population apparent clearance (CL/F) was 68.1 L/h, and mean apparent volume of distribution (V/F) was 28.8 L. Body weight was a covariate of CL/F and V/F. Estimated glomerular filtration rate was a significant covariate of CL/F (P < .001). SLC22A1 genotype did not significantly affect metformin pharmacokinetics. The response to 6 months of metformin treatment (HbA(1c), homeostasis model assessment for insulin resistance, fasting insulin, and glucose changes) did not differ between SLC22A1 wild-type subjects and carriers of presumably low-activity SLC22A1 alleles. However, SLC22A1 variant carriers had smaller reductions in percentage of total trunk fat after metformin therapy, although the percentage reduction in trunk fat was small. The median % change in trunk fat was -2.20% (-9.00% to 0.900%) and -1.20% (-2.40% to 7.30%) for the SLC22A1 wild-type subjects and variant carriers, respectively. Future study is needed to evaluate the effects of SLC22A1 polymorphisms on metformin-mediated weight reduction in obese children.
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