Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume 43, Issue 9, Pages 746-753Publisher
WILEY
DOI: 10.1111/jcpe.12560
Keywords
aggressive periodontitis; chemokines; cytokines; endotoxin; microbiology
Categories
Funding
- NIH/NIDCR [R01DE019456, T32 DE007200]
Ask authors/readers for more resources
AimThe objective of this case-control study was to compare the inflammatory response of peripheral blood from localized aggressive periodontitis (LAP) patients when stimulated with healthy or diseased plaque samples. Materials and MethodsWhole blood and subgingival plaque samples were collected from 13 LAP subjects, 14 siblings of LAP subjects and six periodontally healthy individuals. Whole blood was stimulated for 24h with plaque samples generated from healthy or diseased sites. The levels of 14cyto/chemokines were detected using multiplex technology. ResultsLocalized aggressive periodontitis-derived cultures displayed higher levels of G-CSF, INF, IL10, IL12p40, IL1, IL-6, IL-8, MCP-1, MIP-1, and TNF, than control cultures regardless of stimulus used. Whole blood from healthy siblings displayed higher levels of IL-6 compared to control subjects, but lower levels than those observed in cultures from LAP participants. ConclusionsThis study suggests that although bacteria is an important factor in eliciting the hyper-inflammatory response observed in LAP patients, the predisposition of host's response to bacterial presence may play a more significant role than the components of the stimulatory plaque.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available