Journal
BRITISH JOURNAL OF NUTRITION
Volume 129, Issue 8, Pages 1350-1359Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114522002446
Keywords
One-carbon metabolism; Homocysteine; Choline; Betaine; B-vitamins
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This study aimed to investigate the effects of a light breakfast on serum concentrations of metabolites and B-vitamins related to the one-carbon metabolism. The results showed that the intake of a low nutrient breakfast significantly affected the serum concentrations of several metabolites and B-vitamins.
The transfer of one-carbon units between molecules in metabolic pathways is essential for maintaining cellular homeostasis, but little is known about whether the circulating concentrations of metabolites involved in the one-carbon metabolism are affected by the prandial status. Epidemiological studies do not always consistently use fasting or non-fasting blood samples or may lack information on the prandial status of the study participants. Therefore, the main aim of the present study was to investigate the effects of a light breakfast on serum concentrations of selected metabolites and B-vitamins related to the one-carbon metabolism; i.e. the methionine-homocysteine cycle, the folate cycle, the choline oxidation pathway and the transsulfuration pathway. Sixty-three healthy adults (thirty-six women) with BMI >= 27 kg/m(2) were included in the study. Blood was collected in the fasting state and 60 and 120 min after intake of a standardised breakfast consisting of white bread, margarine, white cheese, strawberry jam and orange juice (2218 kJ). The meal contained low amounts of choline, betaine, serine and vitamins B-2, B-3, B-6, B-9 and B-12. Serum concentrations of total homocysteine, total cysteine, flavin mononucleotide, nicotinamide and pyridoxal 5'-phosphate were significantly decreased, and concentrations of choline, betaine, dimethylglycine, sarcosine, cystathionine and folate were significantly increased following breakfast intake (P < 0 center dot 05). Our findings demonstrate that the intake of a light breakfast with low nutrient content affected serum concentrations of several metabolites and B-vitamins related to the one-carbon metabolism.
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