COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Review Dermatology

Are the chilblain-like lesions observed during the COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2? Systematic review and meta-analysis

V. Sanchez-Garcia et al.

Summary: The meta-analysis found that a small proportion of patients with chilblain-like lesions (CLL) tested positive for COVID-19 through PCR or serology, indicating a low correlation between CLL and COVID-19.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Multidisciplinary Sciences

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Jeff R. Gehlhausen et al.

Summary: An increased incidence of chilblains during the SARS-CoV-2 pandemic has been observed, but there is limited direct evidence linking it with viral infection. This study found that the percentage of prior SARS-CoV-2 infection in patients diagnosed with COVID toes was similar to the background seroprevalence at that time.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Medicine, General & Internal

Comparison of Seroconversion in Children and Adults With Mild COVID-19

Zheng Quan Toh et al.

Summary: This cohort study found that children with mild SARS-CoV-2 infection were less likely to have seroconversion compared to adults, despite similar viral loads. This has implications for understanding protection and interpreting serosurveys involving children.

JAMA NETWORK OPEN (2022)

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Article Dermatology

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series

C. M. Magro et al.

Summary: COVID-19-related perniosis represents an exaggerated immune reaction triggered by the virus with significant type I interferon signaling, which is crucial for SARS-CoV-2 eradication and may lead to a more generalized highly inflammatory response. In the thrombotic retiform purpura of critically ill patients with COVID-19, vascular thrombosis in the skin and other organ systems is associated with a minimal interferon response, allowing excessive viral replication and release of viral proteins that trigger extensive complement activation in extrapulmonary endothelium.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic-Associated Pernio

Lisa M. Arkin et al.

Summary: Despite the large number of patients with pandemic-associated pernio, establishing a causal link to SARS-CoV-2 remains a challenge. Pathophysiological studies suggest that some children with pernio may have abnormalities in IFN-1 immunity, while excessive immune responses to SARS-CoV-2 are seen in the skin of pernio patients.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Dermatology

COVID toes: A meta-analysis of case and observational studies on clinical, histopathological, and laboratory findings

Kelvin Oliveira Rocha et al.

Summary: This study evaluated and summarized the clinical, laboratory, and histopathological characteristics of pernio-like skin lesions associated with COVID-19 infection. The results showed that these lesions mostly occurred in pediatric patients, and the characteristics differed between pediatric and non-pediatric populations. There may be a multifactorial component in the pathophysiology of pernio-like lesions.

PEDIATRIC DERMATOLOGY (2021)

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Article Dermatology

Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic

Roland Aschoff et al.

DERMATOPATHOLOGY (2020)

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COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Related references

Are the chilblain-like lesions observed during the COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2? Systematic review and meta-analysis

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Comparison of Seroconversion in Children and Adults With Mild COVID-19

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic-Associated Pernio

COVID toes: A meta-analysis of case and observational studies on clinical, histopathological, and laboratory findings

Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic

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