4.7 Article

Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing

Related references

Note: Only part of the references are listed.
Article Pathology

Validation and Characterization of FGFR2 Rearrangements in Cholangiocarcinoma with Comprehensive Genomic Profiling

Ian M. Silverman et al.

Summary: The study found that F1CDx is a sensitive, reproducible, and highly concordant method for detecting FGFR2 rearrangements in CCA, effectively identifying patients who may benefit from pemigatinib treatment.

JOURNAL OF MOLECULAR DIAGNOSTICS (2022)

Article Oncology

Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study

Funda Meric-Bernstam et al.

Summary: Futibatinib, a selective FGFR1-4 inhibitor, showed clinical activity in various solid tumors, particularly in FGFR2 fusion/rearrangement-positive intrahepatic cholangiocarcinoma. It also demonstrated efficacy in patients who developed resistance to prior FGFR inhibitors. These findings provide a basis for further clinical trials and highlight the importance of genomic profiling in identifying patients who may benefit from targeted therapy.

CANCER DISCOVERY (2022)

Article Biotechnology & Applied Microbiology

Accurate and efficient detection of gene fusions from RNA sequencing data

Sebastian Uhrig et al.

GENOME RESEARCH (2021)

Article Oncology

Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib

Ian M. Silverman et al.

Summary: The study utilized genomic profiling data to explore the genomic landscape and molecular diversity of patients with cholangiocarcinoma, as well as analyze the clinicogenomics of patients treated with pemigatinib, highlighting the utility of genomic profiling in clinical trials.

CANCER DISCOVERY (2021)

Article Oncology

HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Elspeth A. Bruford et al.

Summary: Gene fusions have been discussed in scientific literature since their discovery in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but a new option proposed by HGNC is the use of double colons as a separator in all databases and articles discussing gene fusions.

LEUKEMIA (2021)

Editorial Material Cell Biology

The 2019 WHO classification of tumours of the digestive system

Iris D. Nagtegaal et al.

HISTOPATHOLOGY (2020)

Review Biochemistry & Molecular Biology

Functions of FGFR2 corrupted by translocations in intrahepatic cholangiocarcinoma

Fangda Li et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Article Oncology

Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma

Sarinya Kongpetch et al.

JCO GLOBAL ONCOLOGY (2020)

Review Gastroenterology & Hepatology

Anatomical, histomorphological and molecular classification of cholangiocarcinoma

Timothy Kendall et al.

LIVER INTERNATIONAL (2019)

Review Oncology

Fibroblast growth factor receptors as treatment targets in clinical oncology

Masaru Katoh

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

Leandro H. Gallo et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Article Genetics & Heredity

Genomic spectra of biliary tract cancer

Hiromi Nakamura et al.

NATURE GENETICS (2015)

Article Oncology

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

Yi-Mi Wu et al.

CANCER DISCOVERY (2013)

Article Biochemistry & Molecular Biology

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

Chi-Chuan Lin et al.

Article Pathology

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma

Benjamin R. Kipp et al.

HUMAN PATHOLOGY (2012)

Article Gastroenterology & Hepatology

Survival analysis of cholangiocarcinoma: A 10-year experience in Malaysia

Ahmad Ramzi Yusoff et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Letter Biotechnology & Applied Microbiology

Integrative genomics viewer

James T. Robinson et al.

NATURE BIOTECHNOLOGY (2011)

Article Cell Biology

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

Zamal Ahmed et al.

CELLULAR SIGNALLING (2010)

Article Biochemistry & Molecular Biology

The human genome browser at UCSC

WJ Kent et al.

GENOME RESEARCH (2002)