☆ 4.7 Review

Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity

BRITISH JOURNAL OF CANCER (2022)

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A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

Beatriz M. Carreno et al.

SCIENCE (2015)

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Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment

Valentino Le Noci et al.

ONCOIMMUNOLOGY (2015)

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Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly(I:C)-induced apoptosis of hepatocellular carcinoma by entry blockade

Yuyi Zhang et al.

CANCER LETTERS (2014)

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Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

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The history of Toll-like receptors - redefining innate immunity

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Yuko Shirota et al.

JOURNAL OF IMMUNOLOGY (2012)

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Two Hundred Years of Cancer Research

Vincent T. DeVita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Innate and Adaptive Immunity: The 2011 Nobel Prize in Physiology or Medicine

Aaron J. Ciechanover et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Natural Innate and Adaptive Immunity to Cancer

Matthew D. Vesely et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

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Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

Sally M. Amos et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

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Antitumor Activity Mediated by CpG: The Route of Administration is Critical

Yanyan Lou et al.

JOURNAL OF IMMUNOTHERAPY (2011)

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Melanoma drug wins US approval

Heidi Ledford

NATURE (2011)

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Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses

Xiaopei Huang et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2010)

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Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

Rupal Ramakrishnan et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

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Spatiotemporal Regulation of Heat Shock Protein 90-Chaperoned Self-DNA and CpG-Oligodeoxynucleotide for Type I IFN Induction via Targeting to Static Early Endosome

Koichi Okuya et al.

JOURNAL OF IMMUNOLOGY (2010)

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The Immunostimulatory Activity of Unmethylated and Methylated CpG Oligodeoxynucleotide Is Dependent on Their Ability To Colocalize with TLR9 in Late Endosomes

Susan D. de Jong et al.

JOURNAL OF IMMUNOLOGY (2010)

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Taro Kawai et al.

NATURE IMMUNOLOGY (2010)

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Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides

George Mutwiri et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

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Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

Fernando E. Sepulveda et al.

IMMUNITY (2009)

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Immunogenic and tolerogenic cell death

Douglas R. Green et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Nucleic acid-sensing toll-like receptors: Beyond ligand search

Kensuke Miyake

ADVANCED DRUG DELIVERY REVIEWS (2008)

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TLR9 as a key receptor for the recognition of DNA

Yutaro Kumagai et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

You-Me Kim et al.

NATURE (2008)

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Sarah E. Ewald et al.

NATURE (2008)

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Signaling to NF-κB by Toll-like receptors

Taro Kawai et al.

TRENDS IN MOLECULAR MEDICINE (2007)

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande et al.

NATURE (2007)

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A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

Stanimir Ivanov et al.

BLOOD (2007)

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Induction of interferon-gamma from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-alpha and tumour necrosis factor-alpha

JD Marshall et al.

IMMUNOLOGY (2006)

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

S Uematsu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Cancer immunotherapy: A treatment for the masses

JN Blattman et al.

SCIENCE (2004)

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Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities

J Vollmer et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

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The leucine-rich repeat as a protein recognition motif

B Kobe et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2001)

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A Toll-like receptor recognizes bacterial DNA

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