Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 103, Issue -, Pages 122-129Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2022.04.010
Keywords
secretory Immunoglobulin A (s-IgA); Acute stress; Children; Adolescents; Childhood maltreatment; Developmental stage; TSST-C
Categories
Funding
- Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III through the University of Barcelona [PI15/00097]
- Hospital Universitario Araba [PI15/00793]
- Hospital Gregorio Maranon [PI15/00723]
- Hospital Clinic [PI15/00685]
- European Regional Development Funds from the European Commission, A way of making Europe
- Comissionat per a Universitats i Recerca del DIUE, of the Generalitat de Catalunya regional authorities [2017SGR1577]
- Ramon y Cajal Research Fellowship [RYC-2017-23144]
- Brain and Behaviour Research Foundation [24628]
- [AGAUR-FI_B100023-2018]
- [AGAUR-FI_B 00233-2020]
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This study investigates the behavior of s-IgA in children and adolescents facing acute psychosocial stress, finding that the response of s-IgA varies depending on developmental stage and history of childhood maltreatment. Interestingly, children without maltreatment do not show changes in s-IgA levels after stress, while those with maltreatment show a similar response to adolescents, with an increase in s-IgA levels after the psychosocial stressor.
Background: Mucosal secretory immunoglobulin A (s-IgA) is an antibody protein-complex that plays a crucial role in immune first defense against infection. Although different immune biomarkers have been associated with stress-related psychopathology, s-IgA remains poorly studied, especially in youth.Objectives: The present study investigated how s-IgA behaves in front of acute psychosocial stress in children and adolescents, including possible variability associated with developmental stage and history of childhood maltreatment (CM).Methods: 94 children and adolescents from 7 to 17 years (54 with a current psychiatric diagnostic and 40 healthy controls) drawn from a larger Spanish study were explored (EPI-Young Stress Project). To assess biological reactivity, participants provided five saliva samples during an acute laboratory-based psychosocial stressor, the Trier Social Stress Test for Children (TSST-C). Samples were assayed for s-IgA, as well as for cortisol. Pubertal development was ascertained by Tanner stage and CM following TASSCV criteria.Results: We observed s-IgA fluctuations throughout the stressor, indicating the validity of TSST-C to stimulate sIgA secretion (F(4,199) = 6.200, p <.001). Although s-IgA trajectories followed a reactivity and recovery pattern in adolescents, children exhibited no s-IgA response when faced with stress (F(4,197) = 3.406, p =.010). An interaction was found between s-IgA and CM (F(4,203) = 2.643, p =.035). Interestingly, an interaction between developmental stage, CM history and s-IgA reactivity was identified (F(12,343) = 2.036, p =.017); while children non-exposed to maltreatment exhibited no s-IgA changes to acute stress, children with a history of CM showed a similar response to adolescents, increasing their s-IgA levels after the psychosocial stressor.
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