4.6 Article

Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study - a prospective population-based cohort study

Journal

BMC PUBLIC HEALTH
Volume 22, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12889-022-13666-z

Keywords

Coronavirus; COVID-19; Pandemic; Surveillance; ELISA; Risk behaviors; Risk factors; Antibodies; Cohort-study

Funding

  1. Projekt DEAL
  2. National Research Network of University Medicine on COVID-19 in surveillance and testing (B-Fast work package 4)
  3. Federal State of Schleswig-Holstein
  4. University of Luebeck

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Considering the spread of new SARS-CoV-2 variants, low vaccination rates, and the risk of post-COVID syndrome, targeted intervention measures are urgently needed. The ELISA-Study is a longitudinal surveillance study that aims to study immunity, post-COVID-19 symptoms, and related risk factors through PCR testing, antibody measurements, and questionnaires. This study enables continuous monitoring of the pandemic and identification of potential long-term effects.
Background: Considering the insufficiently controlled spread of new SARS-CoV-2 variants, partially low vaccination rates, and increased risk of a post-COVID syndrome, well-functioning, targeted intervention measures at local and national levels are urgently needed to contain the SARS-CoV-2 pandemic. Surveillance concepts (cross-sectional, cohorts, clusters) need to be carefully selected to monitor and assess incidence and prevalence at the population level. A critical methodological gap for identifying specific risks/dynamics for SARS-Cov-2 transmission and post-COVID-19-syndrome includes repetitive testing for past or present infection of a defined cohort with simultaneous assessment of symptoms, behavior, risk, and protective factors, as well as quality of life. Methods: The ELISA-Study is a longitudinal, prospective surveillance study with a cohort approach launched in Luebeck in April 2020. The first part comprised regular PCR testing, antibody measurements, and a recurrent App-based questionnaire for a population-based cohort of 3000 inhabitants of Luebeck. The follow-up study protocol includes self-testing for antibodies and PCR testing for a subset of the participants, focusing on studying immunity after vaccination and/or infection and post-COVID-19 symptoms. Discussion: The ELISA cohort and our follow-up study protocol will enable us to study the effects of a sharp increase of SARS-CoV-2 infections on seroprevalence of Anti-SARS-CoV-2 antibodies, post-COVID-19-symptoms, and possible medical, occupational, and behavioral risk factors. We will be able to monitor the pandemic continuously and discover potential sequelae of an infection long-term. Further examinations can be readily set up on an ad-hoc basis in the future. Our study protocol can be adapted to other regions and settings and is transferable to other infectious diseases.

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