Analysis and prognostic significance of tumour immune infiltrates and immune microenvironment of m6A-related lncRNAs in patients with gastric cancer

Article Medicine, General & Internal

Comprehensive Analyses of the Infiltrating Immune Cell Landscape and Its Clinical Significance in Hepatocellular Carcinoma

Zeyu Zhang et al.

Summary: The study revealed that the fractions of Tfh cells, monocytes, M0, and M2 macrophages are closely associated with clinical prognosis and histological grade in HCC.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Article Oncology

Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk

Yimin Cheng et al.

Summary: The study revealed that the NINJ2 gene polymorphism locus rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. Additionally, higher quantities of CEA, CA125 and AFP were found in endometrial cancer patients compared to controls.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular carcinoma

Shen Shen et al.

Summary: This study identified three different m6A modification subtypes in hepatocellular carcinoma (HCC) patients, which were associated with different immune cell infiltration phenotypes in the tumor immune microenvironment (TIME). Low expression of METTL3 was correlated with increased infiltration of dendritic cells (DCs) in the TIME, and patients with low m6A scores had better overall survival and 5-year survival rates.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Biochemical Research Methods

m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma

Jianyang Du et al.

Summary: The study analyzed the m6A RNA methylation patterns in low-grade glioma samples and explored their impact on immune infiltration and sternness, revealing different regulatory patterns and correlations.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Multidisciplinary Sciences

A risk score model with five long non-coding RNAs for predicting prognosis in gastric cancer: an integrated analysis combining TCGA and GEO datasets

Yiguo Wu et al.

Summary: The study aimed to construct a risk score model based on five lncRNAs to predict the prognosis of gastric cancer patients using data from TCGA and independent GEO datasets. The model showed predictive value in both databases and demonstrated independent prognostic value in patients with stage II-IV GC. This model may provide potential therapeutic targets for future treatment.

PEERJ (2021)

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Article Cell Biology

TYMSOS drives the proliferation, migration, and invasion of gastric cancer cells by regulating ZNF703 via sponging miR-4739

Yulan Gu et al.

Summary: This study identified a novel lncRNA TYMSOS plays a critical role in gastric cancer (GC) by promoting tumor growth through regulating proliferation, migration, invasion, and apoptosis of GC cells. TYMSOS may serve as a potential target for GC therapy.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma

Hui Yu et al.

Summary: Lung adenocarcinomas have increased RMRP expression, which is associated with poor prognosis. ALKBH5 upregulates RMRP expression via demethylation, indicating that targeting RMRP through ALKBH5 manipulation could be a promising therapeutic strategy for lung adenocarcinoma.

MAMMALIAN GENOME (2021)

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Article Oncology

M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma

Xinyao Qiu et al.

Summary: This study identifies PD-L1 mRNA as a target of ALKBH5 and reveals a role for ALKBH5 in regulating the tumor immune microenvironment and immunotherapy efficacy. These findings suggest a new regulatory mechanism for PD-L1 involving mRNA epigenetic modification by ALKBH5, as well as a potential role for ALKBH5 in cancer immunotherapies.

CANCER RESEARCH (2021)

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Article Cell Biology

Prognostic signature and immune efficacy of m1A-, m5C- and m6A-related regulators in cutaneous melanoma

Xian rui Wu et al.

Summary: The study on Cutaneous Melanoma (CM) identified specific RNA regulators and their impact on tumor progression, leading to the development of a prognostic risk model and functional pathway analysis. The findings also highlighted the correlation between immune infiltration and immunotherapy response in different risk subgroups of CM patients, contributing to the understanding of molecular heterogeneity in the tumor microenvironment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Medicine, Research & Experimental

The role of M6A modification in the regulation of tumor-related lncRNAs

Yufei Lan et al.

Summary: The article summarizes the important role of N-6-methyladenosine (m(6)A) modification in the regulation and function of tumor-related long non-coding RNAs (lncRNAs), and discusses potential applications and future directions in the field.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer

Fei Ji et al.

Summary: The study found that FOXD2-AS1 is upregulated in cervical cancer and accelerates its progression via METTL3-mediated m(6)A modification. FOXD2-AS1 promotes cell migration and proliferation, highlighting its potential as a therapeutic target for cervical cancer.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Biochemistry & Molecular Biology

Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers

Rui Li et al.

Summary: The study revealed the significant role of N6-methyladenosine RNA modification in the progression of multiple tumorigenesis, with a comprehensive analysis of the regulatory effects of m6A regulators on the tumor immune microenvironment, survival, stemness score, and drug sensitivity in cancer.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer

Ning Cui et al.

Summary: The study found that LINC00511 is up-regulated in gastric cancer and can promote the proliferation and migration of GC cells through the miR-625-5p/STAT3 axis. This suggests that LINC00511 may serve as a therapeutic target for gastric cancer.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p

Hongyan Wang et al.

Summary: This study revealed that LINC00649 promotes gastric cancer progression by regulating the miR-16-5p/YAP1/Hippo signaling pathway, providing potential diagnostic and therapeutic indicators for clinical utilization.

BIOENGINEERED (2021)

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Article Medicine, Research & Experimental

m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer

Wei Chong et al.

Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.

THERANOSTICS (2021)

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Article Oncology

Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer

Rui Bai et al.

Summary: High expression of ANKRD6 is associated with poor prognosis in colon cancer, and it is positively correlated with infiltration levels of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in colon cancer. Immune cell infiltration differences were also observed between ANKRD6-high and ANKRD6-low groups.

CHINESE JOURNAL OF CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology