Journal
BMC GENOMICS
Volume 23, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12864-022-08750-y
Keywords
Echinodermata; Ophiuroidea; Brittle star; Tissue regeneration; Comparative genomics; Notch signaling pathway
Funding
- National Institute for General Medical Sciences of the National Institutes of Health [1R15GM128066-01]
- University of North Florida
- University of North Carolina at Charlotte
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This article presents the draft genome and mitochondrial genome of the brittle star O. brevispinum, providing an important resource for studying regenerative mechanisms. The genomic information will be essential for future research on the molecular mechanisms regulating regeneration.
Background Echinoderms are established models in experimental and developmental biology, however genomic resources are still lacking for many species. Here, we present the draft genome of Ophioderma brevispinum, an emerging model organism in the field of regenerative biology. This new genomic resource provides a reference for experimental studies of regenerative mechanisms. Results We report a de novo nuclear genome assembly for the brittle star O. brevispinum and annotation facilitated by the transcriptome assembly. The final assembly is 2.68 Gb in length and contains 146,703 predicted protein-coding gene models. We also report a mitochondrial genome for this species, which is 15,831 bp in length, and contains 13 protein-coding, 22 tRNAs, and 2 rRNAs genes, respectively. In addition, 29 genes of the Notch signaling pathway are identified to illustrate the practical utility of the assembly for studies of regeneration. Conclusions The sequenced and annotated genome of O. brevispinum presented here provides the first such resource for an ophiuroid model species. Considering the remarkable regenerative capacity of this species, this genome will be an essential resource in future research efforts on molecular mechanisms regulating regeneration.
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