Journal
BMC GASTROENTEROLOGY
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12876-022-02386-8
Keywords
TEADs; Gastric cancer; Biomarkers; Hippo pathway; Prognosis
Categories
Funding
- National Natural Science Foundation of China [82103816]
- Natural Science Foundation of Jiangsu Province [BK20210538, BK20200718]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [20KJB350010]
- Science and Technology Development Funding of Nanjing Medical University [NMUB2020036]
- Priority Discipline Development Program of Jiangsu Higher Education Institutions (General Office, the People's Government of Jiangsu Province) [87]
- National Training Program of Innovation and Entrepreneurship for Undergraduates
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This study evaluated the expression levels of TEADs in gastric cancer samples and observed the clinical outcomes of patients with high TEADs expression. Further analysis suggested that TEADs may serve as prognostic biomarkers or therapeutic targets for gastric cancer.
TEADs are critical transcription factors that participate in the Hippo pathway. Evidence indicates the promotion role of TEADs in cancer progression. However, the role of TEADs and the expression patterns in gastric cancer remains unclear. In this study, we evaluated the expression levels of TEADs in gastric cancer samples, and the clinical outcomes of patients with high TEADs expression were observed. Co-expression and interaction analysis as well as functional enrichment analysis were further conducted to determine the potential role of TEADs in gastric cancer. These results suggested TEADs may serve as the prognostic biomarkers or therapeutic targets for gastric cancer. However, more studies are warranted to verify our findings and promote the application in gastric cancer patients.
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