4.6 Article

TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma

Related references

Note: Only part of the references are listed.
Article Reproductive Biology

TTK is a potential therapeutic target for cisplatin-resistant ovarian cancer

Yixuan Liu et al.

Summary: TTK is up-regulated in cisplatin-resistant ovarian cancer, and down-regulation of TTK can restore sensitivity to cisplatin, with the PI3K/AKT signaling pathway affected by TTK expression.

JOURNAL OF OVARIAN RESEARCH (2021)

Article Biochemistry & Molecular Biology

TTK inhibitor promotes radiosensitivity of liver cancer cells through p21

Haibo Zhang et al.

Summary: The study showed that the TTK inhibitor can enhance the radiosensitivity of liver cancer cells by regulating cell cycle and centrosome abnormalities, leading to apoptosis and necrosis. The TTK inhibitor may be a potential radiosensitizer for patients with liver cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

Su Min Lim et al.

Summary: Autophagy is a cellular process essential for maintaining homeostasis, involving the degradation and recycling of cytosolic materials. In cancer, autophagy plays a dual role, suppressing malignant transformation while supporting cancer cell survival and promoting tumorigenicity. Researchers are investigating the potential of targeting autophagy for cancer therapeutics.

CELL AND BIOSCIENCE (2021)

Review Oncology

An Alternative Pipeline for Glioblastoma Therapeutics: A Systematic Review of Drug Repurposing in Glioblastoma

Sean B. Lyne et al.

Summary: Glioblastoma remains challenging to treat with no new systemic therapies approved in almost two decades. Drug repurposing offers a rapid and cost-effective approach to identifying novel agents for this disease. While most agents have not progressed beyond initial stages, some have shown promising results in early clinical trials.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

Article Medicine, Research & Experimental

TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination

Benjamin C. Chandler et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Oncology

The role of autophagy in resistance to targeted therapies

Luigi Mele et al.

CANCER TREATMENT REVIEWS (2020)

Article Biochemistry & Molecular Biology

TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway

Hongxia Huang et al.

FEBS OPEN BIO (2020)

Article Biochemistry & Molecular Biology

A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

Timo E. F. Kuijt et al.

CURRENT BIOLOGY (2020)

Review Oncology

Targeting autophagy to overcome drug resistance: further developments

Haocai Chang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Oncology

Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma

Zhuoran Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Medicine, Research & Experimental

Autophagy: A novel mechanism of chemoresistance in cancers

Xinyu Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Oncology

Silencing TTK expression inhibits the proliferation and progression of prostate cancer

Saipeng Chen et al.

EXPERIMENTAL CELL RESEARCH (2019)

Article Medicine, Research & Experimental

A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer

Xiangling Chen et al.

THERANOSTICS (2018)

Article Pharmacology & Pharmacy

Mps1/TTK: a novel target and biomarker for cancer

Yuan Xie et al.

JOURNAL OF DRUG TARGETING (2017)

Article Medicine, Research & Experimental

HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells

Shu Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Article Oncology

Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity

Antje M. Wengner et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Oncology

MPS1 kinase as a potential therapeutic target in medulloblastoma

Irina Alimova et al.

ONCOLOGY REPORTS (2016)

Article Oncology

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins

Uday Bhanu Maachani et al.

MOLECULAR CANCER RESEARCH (2015)

Article Oncology

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs

Bakhos A. Tannous et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Review Biochemistry & Molecular Biology

The MPS1 Family of Protein Kinases

Xuedong Liu et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Editorial Material Cell Biology

A chemical tool box defines mitotic and interphase roles for Mps1 kinase

Weijie Lan et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

T Kanzawa et al.

CELL DEATH AND DIFFERENTIATION (2004)

Article Genetics & Heredity

Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray

A Saito-Hisaminato et al.

DNA RESEARCH (2002)