Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 154, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113534
Keywords
SARS-CoV-2; Neurological disorders; Cerebral microvascular; Blood-brain barrier; Inflammatory response; Neurotropism
Funding
- Research & Technology of Ker-manshah University of Medical Sciences (Kermanshah, Iran)
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This review discusses cerebral microvascular disease associated with SARS-CoV-2 infection, which may be due to endothelial cell dysfunction as a part of the blood-brain barrier, accompanied by inflammatory response and blood coagulation disorders.
Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main patho-mechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation disorders. In this review, we described the properties of the BBB, the neurotropism behavior of SARS-CoV-2, and the possible mechanisms of damage to the CNS microvascular upon SARS-CoV-2 infection.
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