Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 151, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113068
Keywords
Hypoxia; Immune escape; HIF; TME; Cancer
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Hypoxia in the tumor microenvironment plays a crucial role in tumor development by regulating stromal elements, including immune cells. Targeting hypoxia can potentially prevent immune escape and inhibit malignant tumor progression.
The physical and chemical pressures in the tumor microenvironment (TME) play an important role in tumor development by regulating stromal elements, including immune cells. Hypoxia can induce a cascade of events in tumor initiation and development via immune regulation. As a dangerous factor, hypoxia activates multiple signaling pathways to reshape the immune microenvironment, leading to immunosuppression. Consequently, targeting hypoxia in the TME is a potential strategy to prevent immune escape and inhibit malignant tumor progression. In this review, we summarized the role of hypoxia-induced factors in the tumor immune escape process and provide a novel pathway to restrain tumor progression and development.
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