Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 151, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113103
Keywords
Maternal obesity; Offspring; Epigenetics; Transcriptomics; Proteomics; Metabolomics
Funding
- National Key Research and Development Program [2021YFC2701003, 2021YFC2701104]
- National Natural Science Foundation of China [82171649, 81871219, 81771595]
- LiaoNing Revitalization Talents Program [XLYC1902099]
- 345 Talent Project of Shengjing Hospital
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Obesity during pregnancy affects obstetric problems and poor outcomes, but the molecular mechanisms behind this are still unclear. This review summarizes the maternal and fetal pathophysiological alterations induced by gestational obesity using omics detection techniques.
Epidemiological studies show that obesity during pregnancy affects more than half of the pregnancies in the developed countries and is associated with obstetric problems and poor outcomes. Obesity tends to increase the incidence of complications. Furthermore, the resulting offspring are also adversely affected. However, the molecular mechanisms of obesity leading to poor pregnancy outcomes remain unclear. Omics methods are used for genetic diagnosis and marker discovery. The aim of this review was to summarize the maternal and fetal pathophysiological alterations induced by gestational obesity,identified using multi-omics detection techniques, and to generalize the biological functions and potential mechanisms of the differentially expressed molecules.
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