Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 151, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113188
Keywords
Alzheimer?s disease; Protein tyrosine phosphatases; ?-amyloid plaques; Tau hyperphosphorylation; Signal transduction
Funding
- Zhejiang Provincial Key Scientific Project [2021C03041]
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Protein tyrosine phosphatases (PTPs) play a significant role in the pathogenesis of Alzheimer's disease (AD) and are closely related to the accumulation of abnormally phosphorylated proteins.
Protein tyrosine phosphatases (PTPs) are important regulator of neuronal signal transduction and a growing number of PTPs have been implicated in Alzheimer's disease (AD). In the brains of patients with AD, there are a variety of abnormally phosphorylated proteins, which are closely related to the abnormal expression and activity of PTPs. beta-Amyloid plaques (A beta) and hyperphosphorylated tau protein are two pathological hallmarks of AD, and their accumulation ultimately leads to neurodegeneration. Studies have shown that protein phosphorylation signaling pathways mediates intracellular accumulation of A beta and tau during AD development and are involved in synaptic plasticity and other stress responses. Here, we summarized the roles of PTPs related to the pathogenesis of AD and analyzed their therapeutic potential in AD.
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