4.8 Article

ROS responsive nanoparticles loaded with lipid-specific AIEgen for atherosclerosis-targeted diagnosis and bifunctional therapy

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis

Qiang Chen et al.

Summary: The study suggests that dual-targeting nanomicelles based on N-Acetylneuraminic acid and Chondroitin sulfate may have a better therapeutic effect in atherosclerosis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Engineering, Environmental

Overexpressed VLA-4 on endothelial cell membrane camouflaging the pathological reactive oxygen species responsive prodrug to enhance target therapy for atherosclerosis

Yuan Zhong et al.

Summary: The biomimetic nanodrugs OEM@RAP NPs were used to enhance the delivery and accumulation of drugs in atherosclerotic plaques, improving the bioavailability and reducing side effects, thus inhibiting the occurrence and development of atherosclerosis.

CHEMICAL ENGINEERING JOURNAL (2022)

Review Pharmacology & Pharmacy

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Jun Chen et al.

Summary: Atherosclerosis is a chronic inflammatory disease caused by lipid accumulation in arteries, leading to narrowing and thrombosis. Nanomaterials have been developed for improving the diagnosis and treatment of atherosclerosis, showing promise in both preclinical and clinical stages.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Multidisciplinary

In Vivo Three-Photon Imaging of Lipids using Ultrabright Fluorogens with Aggregation-Induced Emission

Shaowei Wang et al.

Summary: Organic dots with aggregation-induced emission (AIEgen) have been developed for in vivo labeling and imaging of lipid-rich tissues, showing high targeting specificity and stability, as well as strong three-photon fluorescence imaging in deep tissues under NIR-II laser excitation. This study will inspire the development of lipid-targeting fluorophores for in vivo applications.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Poly-β-cyclodextrin Supramolecular Nanoassembly with a pH-Sensitive Switch Removing Lysosomal Cholesterol Crystals for Antiatherosclerosis

Yan Zhang et al.

Summary: The study utilized poly-beta-cyclodextrin and dextran sulfate grafted with benzimidazole to self-assemble into a supramolecular nanoassembly to address cholesterol crystals in lysosomes. The nanoassembly can release cholesterol crystals in lysosomes, promoting cholesterol efflux and aiding in the regression of atherosclerosis.

NANO LETTERS (2021)

Article Chemistry, Analytical

A lipid droplets specific probe for imaging of atherosclerosis and fibrocalcific bicuspid aortic valves

Shufen Li et al.

Summary: A fluorescent probe MeTT1 was prepared for visualization of LDs in cells and tissues, showing aggregation-induced emission property. MeTT1 exhibited significant fluorescence emission enhancement in oleic acid compared to water, providing a simple tool for studying the pathogenesis of cardiovascular diseases with lipid deposition.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Nanoscience & Nanotechnology

Biomimetic-Coated Nanoplatform with Lipid-Specific Imaging and ROS Responsiveness for Atherosclerosis-Targeted Theranostics

Boxuan Ma et al.

Summary: Atherosclerosis, a major cause of cardiovascular diseases, can be targeted and treated with newly designed nanosized drug carriers that have ROS-responsive properties, showing potential for precise theranostics in atherosclerotic lesions.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Medicine, Research & Experimental

HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter

Chengxiu Hu et al.

Summary: This study demonstrated that Romidepsin modulates VCAM-1 expression to attenuate atherosclerosis by inhibiting HDAC1/2, leading to reduced GATA6 expression and enhanced STAT3 acetylation. Romidepsin was shown to reduce atherosclerotic lesion development by affecting GATA6 methylation in experiments, highlighting the potential therapeutic effect of targeting HDAC1/2 in atherosclerotic heart disease.

THERANOSTICS (2021)

Article Chemistry, Multidisciplinary

A bifunctional mitochondrial targeting AIE-active fluorescent probe with high sensitivity to hydrogen peroxide and viscosity for fatty liver diagnosis

Hong Xu et al.

Summary: In this study, a novel AIE-active bioprobe TPP-Tba was reported for linear fluorescence response and qualitative detection of H2O2 and viscosity, with a wide detection range and low detection limit. The probe shows impressive ability in distinguishing normal cells and pathological cells, as well as efficiently distinguishing fatty liver tissue from normal liver tissue.

NEW JOURNAL OF CHEMISTRY (2021)

Article Materials Science, Biomaterials

Turn-on fluorescent probe for lipid droplet specific imaging of fatty liver and atherosclerosis

Shufen Li et al.

Summary: A novel NIR fluorescent probe TNBD was synthesized with low emission in aqueous solution and solid state, but enhanced emission in oleic acid. It exhibited impressive LD specific fluorescence turn-on ability in cells and disease samples, providing a new way to prepare a NIR LD targeted fluorescence probe.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Medicine, Research & Experimental

Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

Yi Wang et al.

Summary: This study aimed to develop an ideal biomimetic nanoparticle for targeted atherosclerosis (AS) therapy. The results showed that the advanced MM/RAPNPs demonstrated good biocompatibility, effectively inhibited the progression of AS, and displayed favorable safety performance in AS mouse models. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.

THERANOSTICS (2021)

Article Chemistry, Multidisciplinary

Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity

Heegon Kim et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Nanoscience & Nanotechnology

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

Alyssa M. Flores et al.

NATURE NANOTECHNOLOGY (2020)

Review Materials Science, Biomaterials

Applications of inorganic nanoparticles in the diagnosis and therapy of atherosclerosis

Ting Dai et al.

BIOMATERIALS SCIENCE (2020)

Review Cell Biology

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Patricia Marchio et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

Article Chemistry, Multidisciplinary

Multifunctional Block Copolymers for Simultaneous Solubilization of Poorly Water-Soluble Cholesterol and Hydroxyapatite Crystals

Philipp Keckeis et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Article Chemistry, Multidisciplinary

A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

Bo Situ et al.

MATERIALS HORIZONS (2019)

Article Materials Science, Biomaterials

S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE-/- mice

Jooneon Park et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Review Pathology

Potential of anti-inflammatory agents for treatment of atherosclerosis

Dimitry A. Chistiakov et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2018)

Article Biochemistry & Molecular Biology

Choosing the right fluorophore for single-molecule fluorescence studies in a lipid environment

Zhenfu Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

Review Medicine, Research & Experimental

Heart targeted nanoliposomal/nanoparticles drug delivery: An updated review

Mostafa Cheraghi et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Cardiac & Cardiovascular Systems

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis

Ulrich Foerstermann et al.

CIRCULATION RESEARCH (2017)

Article Cardiac & Cardiovascular Systems

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

Ira Tabas et al.

CIRCULATION RESEARCH (2016)

Review Cardiac & Cardiovascular Systems

Coronary Atherosclerosis: Pathophysiologic Basis for Diagnosis and Management

Konstantinos Dean Boudoulas et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2016)

Review Chemistry, Multidisciplinary

Stimuli-responsive nanogel composites and their application in nanomedicine

Maria Molina et al.

CHEMICAL SOCIETY REVIEWS (2015)

Review Medicine, Research & Experimental

Balancing the fat: lipid droplets and human disease

Natalie Krahmer et al.

EMBO MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

Micrometric segregation of fluorescent membrane lipids: relevance for endogenous lipids and biogenesis in erythrocytes

Ludovic D'Auria et al.

JOURNAL OF LIPID RESEARCH (2013)

Review Cardiac & Cardiovascular Systems

Aging and Atherosclerosis Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence

Julie C. Wang et al.

CIRCULATION RESEARCH (2012)

Review Biochemistry & Molecular Biology

Reactive oxygen species in cardiovascular disease

Koichi Sugamura et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Immunology

The immune system in atherosclerosis

Goran K. Hansson et al.

NATURE IMMUNOLOGY (2011)

Review Biotechnology & Applied Microbiology

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

Mark E. Lobatto et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Cardiac & Cardiovascular Systems

Identification of CD44 as a senescence-induced cell adhesion gene responsible for the enhanced monocyte recruitment to senescent endothelial cells

Gyeong In Mun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Review Biochemistry & Molecular Biology

Anti-inflammatory drugs and atherosclerosis

Sarni P. Moubayed et al.

CURRENT OPINION IN LIPIDOLOGY (2007)

Article Chemistry, Multidisciplinary

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

JD Luo et al.

CHEMICAL COMMUNICATIONS (2001)