4.7 Article

Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy

Dominik Brucher et al.

Summary: The iMATCH platform developed in this study allows for the rapid generation of high-purity, high-quantity HCAdVs encoding therapeutic combinations within 3 weeks. This system efficiently integrates up to four expression cassettes and enables organ-specific targeting.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

Article Multidisciplinary Sciences

The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody

Sheena N. Smith et al.

Summary: The research introduces a novel gene therapy platform that enables localized treatment within tumors, increasing both the specificity of antibody transduction and the production of antibodies. It demonstrates that this approach significantly reduces the systemic toxicity of drugs while enhancing therapeutic efficacy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

Mattia Deluigi et al.

Summary: The study identifies new structures of NTSR1 and reveals that different types of agonists and inverse agonists have distinct mechanisms of action on the receptor, providing important insights into receptor activation.

SCIENCE ADVANCES (2021)

Article Genetics & Heredity

Curative gene therapies for rare diseases

Rocio Maldonado et al.

Summary: Diseases caused by DNA alterations can be treated with gene therapy by providing functional copies of the mutated gene. While gene therapy has been tested for 30 years in thousands of clinical trials, there are currently only three authorized gene therapy products in the European Union for treating inherited diseases.

JOURNAL OF COMMUNITY GENETICS (2021)

Review Biochemistry & Molecular Biology

Retargeting adenoviruses for therapeutic applications and vaccines

Michael A. Barry et al.

FEBS LETTERS (2020)

Review Oncology

Exploiting the folate receptor α in oncology

Mariana Scaranti et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Noe B. Mercado et al.

NATURE (2020)

Article Chemistry, Multidisciplinary

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Reza Mohammadinejad et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Multidisciplinary Sciences

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

Shipo Wu et al.

NATURE COMMUNICATIONS (2020)

Review Biochemical Research Methods

Gene delivery for immunoengineering

Sarah Y. Neshat et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

Article Virology

Adenovirus Entry: From Infection to Immunity

Urs F. Greber et al.

ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019 (2019)

Article Multidisciplinary Sciences

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Markus Schmid et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Repairing the Brain: Gene Therapy

Tomas Bjorklund

JOURNAL OF PARKINSONS DISEASE (2018)

Review Engineering, Biomedical

Viral Vectors for Gene Therapy: Translational and Clinical Outlook

Melissa A. Kotterman et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 17 (2015)

Review Pharmacology & Pharmacy

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

Andreas Plueckthun

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

Review Oncology

HER2 expression status in diverse cancers: review of results from 37,992 patients

Min Yan et al.

CANCER AND METASTASIS REVIEWS (2015)

Review Biotechnology & Applied Microbiology

Innate Immunity to Adenovirus

Rodinde Hendrickx et al.

HUMAN GENE THERAPY (2014)

Review Oncology

Going viral with cancer immunotherapy

Brian D. Lichty et al.

NATURE REVIEWS CANCER (2014)

Article Multidisciplinary Sciences

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

Birgit Dreier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biotechnology & Applied Microbiology

A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer

M. K. Magnusson et al.

HUMAN GENE THERAPY (2012)

Review Pharmacology & Pharmacy

Adenovirus receptors: implications for targeting of viral vectors

Niklas Arnberg

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Article Biotechnology & Applied Microbiology

Targeting Adenoviruses with Factor X-Single-Chain Antibody Fusion Proteins

Christopher Y. Chen et al.

HUMAN GENE THERAPY (2010)

Review Virology

Adenovirus receptors: implications for tropism, treatment and targeting

Niklas Arnberg

REVIEWS IN MEDICAL VIROLOGY (2009)

Article Biochemistry & Molecular Biology

A designed ankyrin repeat protein evolved to picomolar affinity to Her2

Christian Zahnd et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Genetic retargeting of adenovirus vectors: functionatity of targeting ligands and their influence on virus viability

MK Magnusson et al.

JOURNAL OF GENE MEDICINE (2002)

Article Oncology

The development and clinical use of trastuzumab (Herceptin)

M Harries et al.

ENDOCRINE-RELATED CANCER (2002)

Review Biochemical Research Methods

Non-viral gene delivery systems

ME Davis

CURRENT OPINION IN BIOTECHNOLOGY (2002)

Article Biotechnology & Applied Microbiology

Hexon gene switch strategy for the generation of chimeric recombinant adenovirus

R Youil et al.

HUMAN GENE THERAPY (2002)

Review Biochemistry & Molecular Biology

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

MA Kay et al.

NATURE MEDICINE (2001)