☆ 4.6 Review

Stimuli-responsive nanoassemblies for targeted delivery against tumor and its microenvironment

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

Related references

Note: Only part of the references are listed.

Article Nanoscience & Nanotechnology

Dual-Responsive and ROS-Augmented Nanoplatform for Chemo/Photodynamic/Chemodynamic Combination Therapy of Triple Negative Breast Cancer

Mengyao Chen et al.

Summary: The study presents a smart pH/ROS-responsive nanoplatform Fe2+@UCM-BBD for tumor combination therapy, which exhibits excellent capability of inducing tumor apoptosis through DNA damage, promoting H2O2 production for CDT, and achieving CDT through ROS-responsive mechanism.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Article Nanoscience & Nanotechnology

GSH-Responsive Drug Delivery System for Active Therapy and Reducing the Side Effects of Bleomycin

Man Zhang et al.

Summary: In this study, PEG-modified hollow mesoporous manganese dioxide nanoparticles were used to load the anti-tumor drug bleomycin. The nanocarrier had excellent responsive therapeutic activation ability and could effectively attenuate the side effects of the drug. Mn2+ exhibited strong paramagnetism and was used for T-1-weighted magnetic resonance imaging in vivo.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Article Biophysics

pH-Responsive DNA nanoassembly for detection and combined therapy of tumor

Chong-Hua Zhang et al.

Summary: The novel cancer theragnostic nanoassembly developed has high biocompatibility, stability, and low toxicity, and can be rapidly activated by the tumor microenvironment for selective fluorescence imaging, chemotherapy, and chemoenzymatic therapy. It shows great potential in cancer diagnosis and efficient therapy.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection

Review Oncology

The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers

Ying Shao et al.

Summary: The investigation of non-angiogenic tumor processes, such as vessel co-option (VC) and vasculogenic mimicry (VM), has revealed their importance in tumor development and resistance to anti-angiogenic drugs. Understanding the underlying cellular and molecular mechanisms of VC and VM is crucial for developing effective treatments. The emerging role of circular RNA (circRNA) in regulating VC and VM processes is also being explored for potential therapeutic strategies.

CANCER AND METASTASIS REVIEWS (2022)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Qianqian Sun et al.

Summary: This review article presents the latest research progress on enhancing CDT antitumor effects through the amplification strategy of oxidative stress triggered by endogenous/exogenous stimuli, categorizing enhanced CDT nanomaterials into three major groups. Representative examples in each category are dissected and discussed in terms of rational design, mechanism of action, and potential medical applications. The challenges and bottlenecks in current CDT development are summarized, along with preliminary directions for future development in order to maximize the potential power of biology and chemistry coordination.

COORDINATION CHEMISTRY REVIEWS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

pH-Responsive size-shrinkable mesoporous silica-based nanocarriers for improving tumor penetration and therapeutic efficacy

Yongju He et al.

Summary: The study presents a size-shrinkable nanocarrier triggered by acid, which efficiently accumulates at the tumor site, penetrates deep into the tumor, and is rapidly cleared from the body. The nanocarrier demonstrates potent antitumor efficacy, showing high potential for solid tumor treatment.

NANOSCALE (2022)

Add to Collection

Review Cell & Tissue Engineering

Tumor Microenvironment Modulating Functional Nanoparticles for Effective Cancer Treatments

Seungyong Shin et al.

Summary: Cancer treatment faces challenges due to the resistance mechanism of cancer cells related to the tumor microenvironment. Utilizing functional nanoparticles to modulate the tumor microenvironment can effectively treat refractory cancer, potentially maximizing cancer treatment efficiency when combined with modern cancer therapeutics.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Shaojun Peng et al.

Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.

ADVANCED SCIENCE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Folic Acid-Decorated β-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy

Huikang Yang et al.

Summary: Folic acid-decorated reduction-sensitive star polymeric nanoparticles were synthesized and used for tumor-targeted MRI and chemotherapy. The nanoparticles efficiently delivered drugs and superparamagnetic iron oxide particles into tumor cells through folate receptor-mediated endocytosis and disulfide bond cleavage.

PHARMACEUTICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect

Zhilin Liu et al.

Summary: Nanomedicine improves the efficiency of delivering antitumor drugs into tumors, but insufficient tumor penetration hampers therapeutic efficacy. Vascular disrupting agent (VDA) nanomedicines selectively destroy immature tumor vessels, block the supply of oxygen and nutrients, and increase vascular permeability, reducing the dependence on enhanced permeability and retention effect. This review discusses the recent progress and application of VDA nanomedicines in cancer therapy, including mechanisms, delivery strategies, and combination therapies.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection

Article Chemistry, Physical

Nanoparticles targeting tumor-associated macrophages: A novel anti-tumor therapy

Siyuan Chen et al.

Summary: The tumor microenvironment is crucial for tumorigenesis, metastasis, and drug resistance. Tumor-associated macrophages (TAMs) play a key role in creating a favorable environment for cancer cells, and nanoparticle-based drug delivery systems offer new approaches for targeting TAMs in cancer therapy. Strategies targeting TAMs with nanoparticles include blocking recruitment, promoting transformation, and diminishing existing TAMs to improve cancer treatment efficiency.

NANO RESEARCH (2022)

Add to Collection

Review Medicine, Research & Experimental

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Ala Amiri et al.

Summary: Nanocarriers, especially exosomes, have the potential to overcome barriers in drug delivery due to their stability and inherent capability to shuttle biomolecules. However, research on exosomes as RNA delivery systems, particularly for mRNA, is limited. Therefore, it is important to investigate the application of exosomes in mRNA-based therapies.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

GSH-Responsive Metal-Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy

Lihua Du et al.

Summary: Immunotherapy has great potential for tumor therapy, but the immunosuppressive tumor microenvironment limits its effectiveness. A multifunctional nanoplatform combining drug delivery and medical imaging can overcome the immunosuppressive microenvironment and improve tumor treatment efficiency.

SMALL (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Susu Xiao et al.

Summary: Local hypoxia is a common feature of solid tumors. In this study, a biocompatible bacteria/nanoparticles biohybrid platform was developed to target breast tumors. The results showed that the biohybrid was able to effectively colonize hypoxic tumors, increasing drug accumulation and reducing toxic side-effects.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Instruments & Instrumentation

A comparative biodistribution study of polymeric and lipid-based nanoparticles

Andreas K. O. Aslund et al.

Summary: The biodistribution of nanoencapsulated bioactive compounds is primarily influenced by the size, shape, chemical composition, and surface properties of the encapsulating nanoparticles. This study compared the biodistribution profiles of two clinically relevant nanoformulations in healthy rats. The results showed significant differences in biodistribution, suggesting potential therapeutic applications in lung and brain cancer for these nanoformulations.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Add to Collection

Review Oncology

Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma

Domenico Ribatti et al.

Summary: Non-angiogenic tumors can grow by vascular co-option and vasculogenic mimicry. Vascular co-option refers to the exploitation of pre-existing vessels by cancer cells, while vasculogenic mimicry involves the formation of channels by cancer cells. This review aims to analyze alternative modes of vascularization in GBM, such as vasculogenic mimicry and trans-differentiation.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Review Oncology

Cancer-associated fibroblasts in breast cancer: Challenges and opportunities

Dengdi Hu et al.

Summary: The tumor microenvironment plays a crucial role in cancer progression, including breast cancer. Cancer-associated fibroblasts (CAFs) are the most abundant components of the tumor microenvironment, promoting breast cancer malignancy through various mechanisms. CAFs have become therapeutic targets due to their unique distribution and biomarkers in tumors. Drugs interrupting the effects of CAFs on surrounding cells have been developed and applied in clinical trials. Summarizing CAF-related studies from a historical perspective can help accelerate the development of CAF-targeted therapeutic strategies for breast cancer.

CANCER COMMUNICATIONS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Nanoparticle-based medicines in clinical cancer therapy

Shuhang Wang et al.

Summary: Nanotechnology offers new solutions for overcoming the limitations of anti-cancer drugs and biological barriers. Considerable technological and clinical success has been achieved in cancer nanomedicine, but there are challenges in translating it into clinical practice. This review introduces the progress and challenges of nanomedicines in clinical trials for cancer therapy, including lipid-based, polymeric, and albumin-based nanoparticles, and highlights promising biomolecule-based nanomedicines for future clinical applications.

NANO TODAY (2022)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Endogenous tumor microenvironment-responsive multifunctional nanoplatforms for precision cancer theranostics

Cong Wang et al.

Summary: Multifunctional nanoplatforms (MFNPs) have the potential to integrate diverse functional diagnostic and therapeutic agents in one system, making them attractive for precision cancer theranostics. Various strategies, including endogenous stimuli-responsive MFNPs, have been developed to enhance the accuracy of MFNPs for cancer theranostics.

COORDINATION CHEMISTRY REVIEWS (2021)

Add to Collection

Review Oncology

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

Bin Wang et al.

Summary: Hypoxic tumor microenvironment (TME) may be a major barrier limiting the efficacy of immunotherapy, through inducing immune suppression and resistance. Targeting hypoxia could enhance the efficacy of immunotherapy and provide a promising combinational therapeutic strategy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Review Oncology

Targeting hypoxic tumor microenvironment in pancreatic cancer

Jinxin Tao et al.

Summary: Pancreatic cancer, characterized by late diagnosis, early metastasis, and poor prognosis, exhibits high lethality globally. The hypoxic microenvironment in pancreatic cancer has extensive effects on biological behaviors and malignant phenotypes, leading to aggressive progression and therapeutic resistance. Innovative therapies targeting the tumor hypoxic microenvironment show great potential in overcoming treatment resistance and enhancing antitumor efficacy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

Xiaoxu Wei et al.

Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.

MOLECULAR CANCER (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment

Yudi Deng et al.

Summary: A nanosystem containing FLG and MAR/MPA nanodrugs was developed to regulate tumor vasculature and TME, inducing vascular normalization and TME reconstruction. The two nanodrugs synergistically improved vascular repairing and TME remodeling, achieving overall therapeutic efficiency in tumor treatment.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Complex Factors and Challenges that Affect the Pharmacology, Safety and Efficacy of Nanocarrier Drug Delivery Systems

Joseph A. Piscatelli et al.

Summary: Major developments in nanomedicines, such as nanoparticles and conjugates, have revolutionized drug delivery capabilities, but there is considerable inter-patient variability seen in the systemic disposition, tumor delivery, and pharmacological effects of NP agents. Evaluating fundamental factors influencing NP disposition is crucial for clinical development.

PHARMACEUTICS (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Synthesis and Antitumor Application of Antiangiogenetic Gold Nanoclusters

Qirong Li et al.

Summary: The study introduces a carrier-free nanodrug in the form of gold nanoclusters with enhanced antiangiogenic properties, achieved by altering the ligand to target specific receptors and inhibit vascular endothelial growth.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Enzyme-Triggered Disassembly of Polymeric Micelles by Controlled Depolymerization via Cascade Cyclization for Anticancer Drug Delivery

Jaehyun Park et al.

Summary: The study utilized specific enzymes with high activity in cancer for cancer diagnosis and tumor-targeted drug delivery. NQO1, an over-expressed enzyme in certain tumor types, inhibits oxidative stress and reacts with QPA to induce micellar structure dissociation for drug release. These findings suggest that NQO1-responsive polymeric micelles have potential for improving therapeutic efficacy in anticancer drug delivery.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy

Zhiliang Li et al.

Summary: Engineering photosensitizers into stimuli-responsive supramolecular nanodrugs enhances the delivery and release of photosensitizers for precise tumor photodynamic therapy. The use of metal-free helical nanofibers formed from the coassembly of cationic porphyrin and ATP shows potential in PDT for cancer treatment, targeting tumor tissues with enhanced efficacy.

ACS NANO (2021)

Add to Collection

Review Pharmacology & Pharmacy

Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma q

Yanhong Liu et al.

Summary: Significant advances in nano delivery systems offer new hope for tumor prevention, diagnosis, and treatment, but challenges persist in achieving clinical therapeutic effects against solid tumors. Biological barriers, such as abnormal tumor vasculature and abundant stroma cells within the tumor microenvironment (TME), impede the penetration and distribution of nanodrugs. Advanced strategies for TME remodeling are reviewed to overcome these obstacles and facilitate intratumoral permeation of nanodrugs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Engineering, Biomedical

'Adhesion and release' nanoparticle-mediated efficient inhibition of platelet activation disrupts endothelial barriers for enhanced drug delivery in tumors

Jinxu Cao et al.

Summary: TM33-GON/TNA disrupts tumor vascular endothelial barriers by inhibiting platelet activation and aggregation, leading to enhanced drug penetration and improved antitumor efficacy of nanomedicines without increasing drug delivery to normal tissues; the treatment exhibits significant efficacy in a murine pancreatic cancer model and carries a low risk of systemic bleeding due to reversible restoration of disrupted endothelial junctions.

BIOMATERIALS (2021)

Add to Collection

Review Nanoscience & Nanotechnology

Combined cancer therapeutics-Tackling the complexity of the tumor microenvironment

Catarina Roma-Rodrigues et al.

Summary: Cancer treatment has not yet found a single solution to selectively kill tumor cells without damaging healthy cells. Nanomedicine, combining multiple substances into one system, shows promise in addressing this challenge. By targeting the tumor microenvironment (TME) with combinatorial therapies using stimuli-responsive nanomaterials, the effectiveness of cancer therapeutics can be enhanced.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

Add to Collection

Review Oncology

Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy

Nada S. Aboelella et al.

Summary: It is well-established that cancer cells are constantly under oxidative stress due to increased metabolism from aberrant growth, leading to elevated levels of reactive oxygen species (ROS). There is a prevalent perception that ROS play a crucial role in promoting tumor initiation, progression, metastasis, and drug resistance. Recent advances suggest that cancer immunotherapies can alter tumor redox to intensify oxidative stress, resulting in enhanced antitumor effects.

CANCERS (2021)

Add to Collection

Review Oncology

Cancer-Associated Fibroblasts as a Common Orchestrator of Therapy Resistance in Lung and Pancreatic Cancer

Andreas Domen et al.

Summary: The tumor microenvironment, specifically cancer-associated fibroblasts (CAFs), play a significant role in therapy resistance and disease progression of cancer through modulating tumor growth, metastasis, and drug access. Targeting CAFs could be a promising strategy to overcome resistance to current therapeutic options in cancer treatment.

CANCERS (2021)

Add to Collection

Review Immunology

Role of cancer-associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer

Rana Mhaidly et al.

Summary: CAF in the tumor microenvironment play crucial roles in promoting tumor growth, modulating immune cell activity, and creating an immunosuppressive microenvironment. Understanding the heterogeneity and functions of CAF is vital for exploring their interactions with immune cells, driving cancer progression, and developing therapeutic strategies targeting CAF subpopulations.

IMMUNOLOGICAL REVIEWS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Recent advances of redox-responsive nanoplatforms for tumor theranostics

Miaomiao Chen et al.

Summary: Nano-biotechnologies integrating diagnosis with therapy offer a promising prospect for cancer theranostics. Developing "smart" theranostic nanoplatforms with specific targeting, precise cargoes release, and non-invasive therapeutics for cancers is crucial in personalized medicine. Exploiting redox-responsive theranostic nanoplatforms to modulate intracellular redox homeostasis, especially in tumor microenvironment characterized by high levels of H2O2 and GSH, has shown significant progress in recent studies.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy

Xian Tang et al.

Summary: A tumor-targeting and rapid gene release nano-courier based on phenylboronic acid (PBA) was constructed to enhance photothermal therapy by delivering PD-L1 siRNA. The nano-courier could effectively penetrate and be taken up by tumors with overexpressed sialic acid residues, leading to efficient PD-L1 silencing and triggering systemic antitumor immune responses, ultimately resulting in the complete ablation of orthotopic tumors and suppression of metastasis and recurrence.

NANO TODAY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The diverse functionality of NQO1 and its roles in redox control

David Ross et al.

Summary: This review summarizes the various roles of NQO1 in cell defense and cellular stress, as well as its potential roles in redox control. The interest in NQO1 lies in its inducibility during cellular stress and its involvement in redox processes. Both exogenous and endogenous substrates for NQO1 have been identified, with active research being conducted on compounds activated by NQO1 and NQO1-targeted drug delivery.

REDOX BIOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

Mingming Zhang et al.

Summary: This review discusses the challenges and mechanisms of nanoparticle infiltration in tumor microenvironment, as well as the strategies for enhancing therapeutic efficacy through adjusting the characteristics and structure of nanoparticles. The comprehensive summary provided in this review aims to guide future research in improving cancer treatment outcomes.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection

Review Oncology

Alternative Vascularization Mechanisms in Tumor Resistance to Therapy

Dorina Belotti et al.

Summary: Tumors rely on blood vessels for growth and metastasis. Different mechanisms of tumor vessel formation have a significant impact on tumor response to therapies, with strategies targeting tumor vasculature showing promise in overcoming drug resistance and improving treatment efficacy.

CANCERS (2021)

Add to Collection

Review Cell Biology

Overview on the Different Patterns of Tumor Vascularization

Domenico Ribatti et al.

Summary: Angiogenesis is crucial in embryogenesis and wound healing, but dysregulation can lead to tumor vascular network formation. Despite the solid scientific foundation, alternative mechanisms like vascular co-option and vasculogenic mimicry challenge conventional understanding of tumor vascularization and resistance to anti-angiogenic therapy.

CELLS (2021)

Add to Collection

Review Cell Biology

The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Jorge Martinez et al.

Summary: Desmoplastic tumors exhibit unique tissue structure with abnormal extracellular matrix deposition. Type I collagen is a major component linked to tumor cell survival and metastasis. Previous notion of desmoplasia as a reaction to tumor cells is challenged by findings of preexisting desmoplasia in breast tissue.

CELLS (2021)

Add to Collection

Review Cell Biology

Different Forms of Tumor Vascularization and Their Clinical Implications Focusing on Vessel Co-option in Colorectal Cancer Liver Metastases

Gwendolyn Haas et al.

Summary: Anti-angiogenic treatment targeting sprouting angiogenesis has been established in the modern therapy of metastatic colorectal cancer, particularly in the treatment of liver metastases. However, the clinical benefits are still limited, possibly due to the alternate mechanism of vessel co-option that occurs in a significant fraction of cases. Vessel co-option may lead to an impaired treatment response and inferior survival compared to angiogenic subgroups in colorectal cancer liver metastases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Review Cell Biology

The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

Yanghong Ni et al.

Summary: The tumor microenvironment plays a crucial role in regulating immune escape, drug resistance, progression, and metastasis of malignant cells, as interactions between cancer cells and non-malignant cells often promote drug resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Dynamic nanoassemblies for imaging and therapy of neurological disorders

Lingxiao Zhang et al.

Summary: The rising incidence of neurological disorders has led to increased interest in using nanomedicines, specifically dynamic nanoassemblies, for diagnosis and treatment. Functional nanoparticles are being explored as building blocks for these assemblies, which show promise in targeting brain lesions and enhancing diagnostic and therapeutic efficacy for improved patient outcomes.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature

Xi Hu et al.

Summary: DNDDS has evolved from being a curiosity to a promising strategy for disease diagnosis and therapy. Understanding the dynamic nano-bio interaction between DNDDS and biological systems is crucial for precise spatiotemporal and functional control in vivo.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Engineering stromal heterogeneity in cancer

Leon Jia Wei Tang et al.

Summary: Advancements in single-cell technologies have increased our understanding of stromal heterogeneity, leading to the incorporation of this knowledge in tumor modeling for drug development and personalized drug testing. This approach may result in the development of more precise drugs targeting specific stromal cell subpopulations and improved recapitulation of patient tumors in vitro for personalized drug testing.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells

Nianxiu Duan et al.

Summary: The selective delivery of chemotherapeutics and modulators to tumor cells and activated pancreatic stellate cells (aPSCs) using a prodrug-based smart liposome system shows promising efficacy for pancreatic cancer therapy, with increased accumulation in tumors and reduced side effects.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy

Xueqing Li et al.

Summary: This study develops a hypoxia-responsive nanocomposite for mild-photothermal therapy through gene editing in tumors. The technology has the potential to enhance tumor ablation efficiency and reduce damage to surrounding healthy tissues.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Article Engineering, Biomedical

Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

Jing Liu et al.

Summary: The development of hypoxia-activatable polymeric micelles for tumor-targeted therapy is effective for eradicating advanced breast cancer by triggering synergistic cytotoxicity and immunogenic cell death. These micelles efficiently deliver drugs and photosensitizers to cancer cells, and have the potential to significantly suppress tumor recurrence and metastasis.

BIOMATERIALS (2021)

Add to Collection

Article Engineering, Biomedical

Multistage-responsive nanovehicle to improve tumor penetration for dual-modality imaging-guided photodynamic-immunotherapy

Yi Feng et al.

Summary: This study developed a tumor microenvironment-responsive nanocarrier for on-demand release of therapeutic agents and a photosensitizer, achieving enhanced tumor penetration and uptake through enzyme and redox reactions. By blocking immune checkpoints and enhancing antitumor immune responses, the platform significantly improves therapeutic outcomes.

BIOMATERIALS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular normalization

Kai Wang et al.

Summary: One major issue in cancer treatment is resistance to chemotherapeutic drugs, often associated with abnormal blood vessels. Jain's vascular normalization theory has been applied effectively to drug-resistant tumor treatment. By using angiogenesis inhibitors, remodeling abnormal vessel structure and function can maximize the efficacy of chemotherapeutic drugs.

DRUG DISCOVERY TODAY (2021)

Add to Collection

Review Immunology

Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment

Melanie Desbois et al.

Summary: Cancer immunotherapies have revolutionized cancer treatment, but many patients still exhibit resistance to these therapies. Recent studies have highlighted the significant role of cancer-associated fibroblasts (CAFs) in immune regulation, impacting the tumor immune microenvironment and response to immunotherapies.

IMMUNOLOGICAL REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Design and Engineering of Hypoxia and Acidic pH Dual-Stimuli-Responsive Intelligent Fluorescent Nanoprobe for Precise Tumor Imaging

Shiya Chen et al.

Summary: Hypoxia and acidic pH are chosen as dual stimuli to fabricate a dual lock-and-key fluorescent nanoprobe for highly specific and precise imaging of tumor cells. This nanoprobe successfully applies in a tumor-bearing mice model, indicating the potential for early diagnosis and assessment of cancer treatment.

SMALL (2021)

Add to Collection

Article Engineering, Biomedical

Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition

Mohammad Taleb et al.

Summary: The study demonstrates the use of peptide nanoparticles to modulate both tumor vasculature and immune systems for synergistic tumor suppression. Increasing intratumoral infiltration of immune cells through vascular normalization, while simultaneously inhibiting the PD-L1 immune checkpoint function, reactivates effective immune responses against tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based combo nanoagent together with PD-L1 blockade in reversing multidrug resistance

Weixi Jiang et al.

Summary: This study demonstrates a significant enhancement in therapeutic efficacy against MDR cells and syngeneic tumors using a combo nanoagent equipped with triple synergistic strategies. These strategies include tumor targeting and penetrating capabilities, proton sponge effect, and scavenging endogenous glutathione, combined with photoacoustic imaging for visualization. Moreover, the nanoparticles combined with PD-1/PD-L1 blockade therapy can activate immunological responses and inhibit P-gp expression to eliminate primary and metastatic tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Add to Collection

Review Oncology

Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities

Jordi Alcaraz et al.

Summary: Lung cancer is the leading cause of cancer-related death worldwide, with the stroma of lung cancer and other solid tumors being rich in tumor-associated fibroblasts (TAFs) exhibiting an activated/myofibroblast-like phenotype. Growing evidence suggests that TAFs support key steps of tumor progression and are epigenetically reprogrammed compared to healthy fibroblasts. The mechanisms underlying this reprogramming involve interactions with cancer cells, pro-fibrotic cytokines, extracellular matrix stiffness, smoking particles, and other environmental cues, leading to DNA hypomethylation and selective transcriptional repression in lung TAFs.

CANCERS (2021)

Add to Collection

Article Medicine, Research & Experimental

Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem

Junjie Ren et al.

Summary: The study introduces a new therapeutic strategy of inducing redox dyshomeostasis by inhibiting glutaminolysis and accumulating ROS, which triggers immunogenic cell death to suppress tumor cell proliferation. Utilizing custom-made nanoparticles with ultrasound-activated therapy can effectively disrupt redox homeostasis within tumor cells.

THERANOSTICS (2021)

Add to Collection

Article Medicine, Research & Experimental

ATP-triggered mitochondrial cascade reactions for cancer therapy with nanoscale zeolitic imidazole framework-90

Wei Pan et al.

Summary: The utilization of ATP-triggered strategy with nanoscale ZIF-90 to initiate mitochondrial cascade reactions for cancer therapy is crucial, leading to continuous oxidative stress and apoptosis of cancer cells.

THERANOSTICS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects

Ruirui Li et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Review Pharmacology & Pharmacy

Tumor microenvironment responsive drug delivery systems

Qunye He et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Review Peripheral Vascular Disease

Pathological features of vessel co-option versus sprouting angiogenesis

Emily Latacz et al.

ANGIOGENESIS (2020)

Add to Collection

Review Peripheral Vascular Disease

Vessel co-option and resistance to anti-angiogenic therapy

Elizabeth A. Kuczynski et al.

ANGIOGENESIS (2020)

Add to Collection

Article Engineering, Biomedical

Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer immunotherapy

Yijia Liu et al.

BIOMATERIALS (2020)

Add to Collection

Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery

Prashant Dogra et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Extremely Small Iron Oxide Nanoparticle-Encapsulated Nanogels as a Glutathione-Responsive T1 Contrast Agent for Tumor-Targeted Magnetic Resonance Imaging

Yi Cao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection

Review Nanoscience & Nanotechnology

Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

Nan Yang et al.

NANO-MICRO LETTERS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Mohamed Haider et al.

PHARMACEUTICS (2020)

Add to Collection

Article Engineering, Biomedical

Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes

Maxim P. Nikitin et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Nano-therapeutics for modulating the tumour microenvironment: Design, development, and clinical translation

Siddharth Adityan et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation

Liang Ee Low et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for Enhanced Tumor Chemo-Immunotherapy

Ke Li et al.

ACS NANO (2020)

Add to Collection

Review Chemistry, Physical

Application of gelatin nanoconjugates as potential internal stimuli-responsive platforms for cancer drug delivery

Arif Hussain et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

Add to Collection

Review Biotechnology & Applied Microbiology

Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis

Hermann B. Frieboes et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Add to Collection

Article Cell Biology

A combined eat me/don't eat me strategy based on extracellular vesicles for anticancer nanomedicine

Zakia Belhadj et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion

Xiao Dong et al.

NANO LETTERS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

A Hypoxia-Responsive Albumin-Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

Guangbao Yang et al.

ADVANCED MATERIALS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Size Switchable Nanoclusters Fueled by Extracellular ATP for Promoting Deep Penetration and MRI-Guided Tumor Photothermal Therapy

Zhanwei Zhou et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Add to Collection

Review Pharmacology & Pharmacy

Vascular Disrupting Agents in cancer treatment: Cardiovascular toxicity and implications for co-administration with other cancer chemotherapeutics

Jason H. Gill et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Catalytically Selective Chemotherapy from Tumor-Metabolic Generated Lactic Acid

Zhimin Tian et al.

SMALL (2019)

Add to Collection

Article Nanoscience & Nanotechnology

GSH-Activatable NIR Nanoplatform with Mitochondria Targeting for Enhancing Tumor-Specific Therapy

Guoliang Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Article Physiology

The Acidic Tumor Microenvironment as a Driver of Cancer

Ebbe Boedtkjer et al.

Annual Review of Physiology (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Co-Administration Of iRGD Enhances Tumor-Targeted Delivery And Anti-Tumor Effects Of Paclitaxel-Loaded PLGA Nanoparticles For Colorectal Cancer Treatment

Yi Zhong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Add to Collection

Article Nanoscience & Nanotechnology

ROS-Activated Ratiometric Fluorescent Polymeric Nanoparticles for Self-Reporting Drug Delivery

Mei Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Add to Collection

Article Nanoscience & Nanotechnology

Design and Development of Graphene Oxide Nanoparticle/Chitosan Hybrids Showing pH-Sensitive Surface Charge-Reversible Ability for Efficient Intracellular Doxorubicin Delivery

Xubo Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy

Yijing Liu et al.

ACS NANO (2018)

Add to Collection

Article Engineering, Biomedical

Inhibition of intrinsic coagulation improves safety and tumor-targeted drug delivery of cationic solid lipid nanoparticles

Xuan Wu et al.

BIOMATERIALS (2018)

Add to Collection

Article Medicine, Research & Experimental

Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy

Lijia Jing et al.

THERANOSTICS (2018)

Add to Collection

Review Pharmacology & Pharmacy

Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems

Wenbo Zhan et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Add to Collection

Review Oncology

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Francesco Di Virgilio et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Review Biology

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

Yanqing Huang et al.

SCIENCE CHINA-LIFE SCIENCES (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Polyphenol-Inspired Facile Construction of Smart Assemblies for ATP- and pH-Responsive Tumor MR/Optical Imaging and Photothermal Therapy

Xiao-Rong Song et al.

SMALL (2017)

Add to Collection

Review Immunology

Multifaceted effects of extracellular Adenosine Triphosphate and Adenosine in the Tumor-Host interaction and Therapeutic Perspectives

Paola de Andrade Mello et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment

Bo Jiang

GENES & DISEASES (2017)

Add to Collection

Article Chemistry, Multidisciplinary

ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy

Xiaoding Xu et al.

ADVANCED MATERIALS (2017)

Add to Collection

Article Engineering, Biomedical

Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release

Huicong Zhou et al.

ACTA BIOMATERIALIA (2017)

Add to Collection

Article Nanoscience & Nanotechnology

Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability

Yang Kang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging-Guided Tumor Photothermal Therapy

Linlin Li et al.

ACS NANO (2016)

Add to Collection

Article Engineering, Biomedical

A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan

Xingli Cun et al.

ACTA BIOMATERIALIA (2016)

Add to Collection

Article Engineering, Biomedical

A highly tumor-specific light-triggerable drug carrier responds to hypoxic tumor conditions for effective tumor treatment

Wooram Park et al.

BIOMATERIALS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis

Yue Yuan et al.

NANO LETTERS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Sophia Frentzas et al.

NATURE MEDICINE (2016)

Add to Collection

Review Cell Biology

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E. Panieri et al.

CELL DEATH & DISEASE (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles

Jinping Lai et al.

ACS NANO (2015)

Add to Collection

Review Chemistry, Multidisciplinary

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

Mengxiao Yu et al.

ACS NANO (2015)

Add to Collection

Review Pharmacology & Pharmacy

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

Hiroshi Maeda

ADVANCED DRUG DELIVERY REVIEWS (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Optimized Metal-Organic-Framework Nanospheres for Drug Delivery: Evaluation of Small-Molecule Encapsulation

Jia Zhuang et al.

ACS NANO (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting

Qin Dai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery

Ran Mo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

Daishun Ling et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection

Review Medicine, Research & Experimental

Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

Hisataka Kobayashi et al.

THERANOSTICS (2014)

Add to Collection

Article Engineering, Biomedical

Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery

Shang-Hsiu Hu et al.

ADVANCED HEALTHCARE MATERIALS (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Dual-targeting of αvβ3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo

Ewelina Kluza et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Improvement of drug safety by the use of lipid-based nanocarriers

Sok Bee Lim et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

Carl D. Walkey et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Add to Collection

Article Nanoscience & Nanotechnology

Multicomponent folate-targeted magnetoliposomes: design, characterization, and cellular uptake

Geoffrey D. Bothun et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Add to Collection

Review Oncology

Tumour vascularization: sprouting angiogenesis and beyond

Femke Hillen et al.

CANCER AND METASTASIS REVIEWS (2007)

Add to Collection

Review Oncology

The signaling mechanism of ROS in tumor progression

Wen-Sheng Wu

CANCER AND METASTASIS REVIEWS (2006)

Add to Collection

Article Biochemistry & Molecular Biology

MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression

NE Sounni et al.

FASEB JOURNAL (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.