Related references
Note: Only part of the references are listed.Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling
Wan-Li Cheng et al.
ACTA PHYSIOLOGICA (2022)
The yin and yang of Tbx5 variant effects on sodium channel function
Nicholas P. Kerr et al.
CARDIOVASCULAR RESEARCH (2022)
Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias
Houria Daimi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome
Paloma Nieto-Marin et al.
CARDIOVASCULAR RESEARCH (2022)
Genetics in Congenital Heart Diseases Unraveling the Link Between Cardiac Morphogenesis, Heart Muscle Disease, and Electrical Disorders
Anwar Baban et al.
HEART FAILURE CLINICS (2022)
Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1
Binbin Yang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)
Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction
Zeina R. Al Sayed et al.
CARDIOVASCULAR RESEARCH (2021)
Zfhx3 Transcription Factor Represses the Expression of SCN5A Gene and Decreases Sodium Current Density (INa)
Marcos Rubio-Alarcon et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Genetic insight into sick sinus syndrome
Rosa B. Thorolfsdottir et al.
EUROPEAN HEART JOURNAL (2021)
Advances in targeting 'undruggable' transcription factors with small molecules
Matthew J. Henley et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
Open-state structure and pore gating mechanism of the cardiac sodium channel
Daohua Jiang et al.
CELL (2021)
Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases
Arina O. Degtyareva et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery
Sofia Miron-Barroso et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Targeting of Potassium Channels in Cardiac Arrhythmias
Shira Burg et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2021)
Direct and Indirect Suppression of Scn5a Gene Expression Mediates Cardiac Na+ Channel Inhibition by Wnt Signalling
Aizhu Lu et al.
CANADIAN JOURNAL OF CARDIOLOGY (2020)
The promise and challenge of therapeutic genome editing
Jennifer A. Doudna
NATURE (2020)
Transcriptional Patterning of the Ventricular Cardiac Conduction System
Ozanna Burnicka-Turek et al.
CIRCULATION RESEARCH (2020)
Tuning up Transcription Factors for Therapy
Attila Becskei
MOLECULES (2020)
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation
Antoinette F. van Ouwerkerk et al.
CIRCULATION RESEARCH (2020)
ISL1 loss-of-function variation causes familial atrial fibrillation
Shao-Hui Wu et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS (2020)
Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand
Pattarapong Makarawate et al.
HEART RHYTHM (2020)
Gating and Regulation of KCNQ1 and KCNQ1+KCNE1 Channel Complexes
Yundi Wang et al.
FRONTIERS IN PHYSIOLOGY (2020)
Inherited cardiac arrhythmias
Peter J. Schwartz et al.
NATURE REVIEWS DISEASE PRIMERS (2020)
Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells
Hongyi Zhao et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer
Vincent W. W. van Eif et al.
CIRCULATION RESEARCH (2020)
The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval
David Tinaquero et al.
SCIENTIFIC REPORTS (2020)
ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia-Reperfusion Injury and Inflammatory Reaction
Ke Ning et al.
BIOMED RESEARCH INTERNATIONAL (2020)
Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation
Lu-Chen Weng et al.
CIRCULATION-GENOMIC AND PRECISION MEDICINE (2020)
Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X
Florentina Pluteanu et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
Adela Herraiz-Martinez et al.
CARDIOVASCULAR RESEARCH (2019)
Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes
Fikri Taufiq et al.
CIRCULATION JOURNAL (2019)
Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing Nav1.5 expression in mice
Rong Huo et al.
HEART RHYTHM (2019)
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice
Wenli Dai et al.
ELIFE (2019)
GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations
Brenton R. Swenson et al.
PLOS ONE (2019)
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
Brigitte Laforest et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of Nav1.5 expression in HL-1 cardiomyocytes
Limei Zhao et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)
Peptide therapeutics that directly target transcription factors
Ichiro Inamoto et al.
PEPTIDE SCIENCE (2019)
Cardiac Kir2.1 and Nav1.5 Channels Traffic Together to the Sarcolemma to Control Excitability
Daniela Ponce-Balbuena et al.
CIRCULATION RESEARCH (2018)
Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation
Alexander T. Mikhailov et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2018)
Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats
Kimiko Masuda et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2018)
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
Jessica van Setten et al.
NATURE COMMUNICATIONS (2018)
RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA
Anyu Zhou et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)
Brugada Syndrome-Associated Genetic Loci Are Associated With J-Point Elevation and an Increased Risk of Cardiac Arrest
Laura Andreasen et al.
FRONTIERS IN PHYSIOLOGY (2018)
Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes
Mariana Argenziano et al.
STEM CELL REPORTS (2018)
Recent Advances in Short QT Syndrome
Oscar Campuzano et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)
Disease Modifiers of Inherited SCN5A Channelopathy
Arie O. Verkerk et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)
Constrained α-Helical Peptides as Inhibitors of Protein-Protein and Protein-DNA Interactions
Siddhartha Roy et al.
BIOMEDICINES (2018)
Potassium channels in the heart: structure, function and regulation
Eleonora Grandi et al.
JOURNAL OF PHYSIOLOGY-LONDON (2017)
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci
Ji-Young Lee et al.
EUROPEAN HEART JOURNAL (2017)
Genetics of Atrial Fibrillation: State of the Art in 2017
Diane Fatkin et al.
HEART LUNG AND CIRCULATION (2017)
Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart
Anna Tarradas et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)
PITX2-dependent gene regulation in atrial fibrillation and rhythm control
Fahima Syeda et al.
JOURNAL OF PHYSIOLOGY-LONDON (2017)
Atrial fibrillation: Therapeutic potential of atrial K+ channel blockers
Ursula Ravens et al.
PHARMACOLOGY & THERAPEUTICS (2017)
MOLECULAR PATHOPHYSIOLOGY OF CONGENITAL LONG QT SYNDROME
M. S. Bohnen et al.
PHYSIOLOGICAL REVIEWS (2017)
Tbx20 controls the expression of the KCNH2 gene and of hERG channels
Ricardo Caballero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Fifteen Genetic Loci Associated With the Electrocardiographic P Wave
Ingrid E. Christophersen et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2017)
Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone
Raquel G. Utrilla et al.
FRONTIERS IN PHYSIOLOGY (2017)
Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity
Adam C. Wilkinson et al.
CELL SYSTEMS (2017)
A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population
Feng Wang et al.
CELL DISCOVERY (2017)
The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity
Christiaan C. Veerman et al.
CIRCULATION RESEARCH (2017)
MED12 regulates a transcriptional network of calcium-handling genes in the heart
Kedryn K. Baskin et al.
JCI INSIGHT (2017)
Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands With Brugada Syndrome A Japanese Multicenter Registry
Kenichiro Yamagata et al.
CIRCULATION (2017)
Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population
Lian Liu et al.
CANADIAN JOURNAL OF CARDIOLOGY (2017)
Cryo-EM Structure of the Open Human Ether-a-go-go-Related K+ Channel hERG
Weiwei Wang et al.
CELL (2017)
T-Box Genes in Human Development and Disease
T. K. Ghosh et al.
T-BOX GENES IN DEVELOPMENT AND DISEASE (2017)
Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling
Estefania Lozano-Velasco et al.
CARDIOVASCULAR RESEARCH (2016)
Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L
Marta Perez-Hernandez et al.
CARDIOVASCULAR RESEARCH (2016)
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias
Akiko Koizumi et al.
EUROPEAN HEART JOURNAL (2016)
Cardiac expression of the CREM repressor isoform CREM-IbΔC-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes
J. S. Schulte et al.
BASIC RESEARCH IN CARDIOLOGY (2016)
PITX2: a master regulator of cardiac channelopathy in atrial fibrillation?
Na Li et al.
CARDIOVASCULAR RESEARCH (2016)
Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
Marcos Matamoros et al.
CARDIOVASCULAR RESEARCH (2016)
Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis
Luis Luna-Zurita et al.
CELL (2016)
M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells
Endang Mahati et al.
CIRCULATION JOURNAL (2016)
A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels
Milena B. Furtado et al.
DIFFERENTIATION (2016)
Activation of Wnt/β-catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression
Ning Wang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Valsartan ameliorates KIR2.1 in rats with myocardial infarction via the NF-κB-miR-16 pathway
Xinran Li et al.
GENE (2016)
Transcription factor ETV1 is essential for rapid conduction in the heart
Akshay Shekhar et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
Fahima Syeda et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)
Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm
Rangarajan D. Nadadur et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Irx3 is required for postnatal maturation of the mouse ventricular conduction system
Kyoung-Han Kim et al.
SCIENTIFIC REPORTS (2016)
Electric-Pulse Current Stimulation Increases If Current in mShox2 Genetically Modified Canine Mesenchymal Stem Cells
Yuanyuan Feng et al.
CARDIOLOGY (2015)
Investigating the Transcriptional Control of Cardiovascular Development
Irfan S. Kathiriya et al.
CIRCULATION RESEARCH (2015)
Molecular Regulation of Cardiomyocyte Differentiation
Sharon L. Paige et al.
CIRCULATION RESEARCH (2015)
Inherited progressive cardiac conduction disorders
Alban-Elouen Baruteau et al.
CURRENT OPINION IN CARDIOLOGY (2015)
Molecular basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications
Mohammad M. Al-Qattan et al.
GENE (2015)
The cardiac sodium channel gene SCN5A and its gene product Nav1.5: Role in physiology and pathophysiology
Christiaan C. Veerman et al.
GENE (2015)
Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development
Kesavan Meganathan et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)
Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity
Tatjana Dorn et al.
STEM CELLS (2015)
Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation
Yufeng Huang et al.
PLOS GENETICS (2015)
SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability
Vittoria Ionta et al.
STEM CELL REPORTS (2015)
Up-regulation of miR-21 and miR-23a Contributes to As2O3-induced hERG Channel Deficiency
Xin Zhao et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)
Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents
Ricardo Gomez et al.
CARDIOVASCULAR RESEARCH (2014)
Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation
Moritz F. Sinner et al.
CIRCULATION (2014)
Pitx2, an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc Genes
Ye Tao et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2014)
Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias
Matthew E. Hartman et al.
FASEB JOURNAL (2014)
ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene
Dan Hu et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)
Gain-of-Function KCNH2 Mutations in Patients with Brugada Syndrome
Qi Wang et al.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2014)
Deletion of FoxO1 leads to shortening of QRS by increasing Na+ channel activity through enhanced expression of both cardiac Nav1.5 and β3 subunit
Benzhi Cai et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)
Atrial Fibrillation Associated Chromosome 4q25 Variants Are Not Associated with PITX2c Expression in Human Adult Left Atrial Appendages
Shamone R. Gore-Panter et al.
PLOS ONE (2014)
Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis
Diego Franco et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2014)
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore
Irene Amoros et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Arsenic trioxide-induced hERG K+ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression
Ying Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Chronic atrial fibrillation up-regulates 1-Adrenoceptors affecting repolarizing currents and action potential duration
Marta Gonzalez de la Fuente et al.
CARDIOVASCULAR RESEARCH (2013)
A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation
Morten Salling Olesen et al.
CARDIOVASCULAR RESEARCH (2013)
Reduced Sodium Channel Function Unmasks Residual Embryonic Slow Conduction in the Adult Right Ventricular Outflow Tract Short Communication
Bas J. Boukens et al.
CIRCULATION RESEARCH (2013)
A Missense Mutation in the Sodium Channel 2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome
Helena Riuro et al.
HUMAN MUTATION (2013)
A heterozygous missense SCN5A mutation associated with early repolarization syndrome
Ning Li et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina et al.
NATURE GENETICS (2013)
Functional Characterization of a Novel Frameshift Mutation in the C-terminus of the Nav1.5 Channel Underlying a Brugada Syndrome with Variable Expression in a Spanish Family
Pablo Dolz-Gaiton et al.
PLOS ONE (2013)
CREB critically regulates action potential shape and duration in the adult mouse ventricle
J. S. Schulte et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)
Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients
Yoshihiro Minamiya et al.
CANCER BIOMARKERS (2012)
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells
Martijn L. Bakker et al.
CARDIOVASCULAR RESEARCH (2012)
Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology
Nathalie Gaborit et al.
DEVELOPMENT (2012)
Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8
Hector Barajas-Martinez et al.
HEART RHYTHM (2012)
Novel Mutations in the KCND3-Encoded Kv4.3 K+ Channel Associated with Autopsy-Negative Sudden Unexplained Death
John R. Giudicessi et al.
HUMAN MUTATION (2012)
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer
Malou van den Boogaard et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
TBX5 drives Scn5a expression to regulate cardiac conduction system function
David E. Arnolds et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death
Iris C. R. M. Kolder et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)
Sangamo's lead zinc-finger therapy flops in diabetic neuropathy
Michael Eisenstein
NATURE BIOTECHNOLOGY (2012)
hERG K+ CHANNELS: STRUCTURE, FUNCTION, AND CLINICAL SIGNIFICANCE
Jamie I. Vandenberg et al.
PHYSIOLOGICAL REVIEWS (2012)
Reactive Oxygen Species Suppress Cardiac NaV1.5 Expression through Foxo1
Weike Mao et al.
PLOS ONE (2012)
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia
Michelle L. Milstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Beyond membrane channelopathies: alternative mechanisms underlying complex human disease
Konstantinos Dean Boudoulas et al.
ACTA PHARMACOLOGICA SINICA (2011)
The Emerging Genetic Landscape Underlying Cardiac Conduction System Function
David E. Arnolds et al.
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2011)
Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes Kv1.5 channels in HL-1 cells
Y. K. Ting et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Pitx2c Modulates Cardiac-Specific Transcription Factors Networks in Differentiating Cardiomyocytes from Murine Embryonic Stem Cells
Estefania Lozano-Velasco et al.
CELLS TISSUES ORGANS (2011)
Nuclear Factor κB Downregulates the Transient Outward Potassium Current Ito,f Through Control of KChIP2 Expression
Brian K. Panama et al.
CIRCULATION RESEARCH (2011)
PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression
Paulus Kirchhof et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2011)
PITX2 Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis
Ana Chinchilla et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2011)
Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
John R. Giudicessi et al.
HEART RHYTHM (2011)
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function
Tao Shen et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
The mechanisms underlying ICa heterogeneity across murine left ventricle
Lin Xu et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2011)
Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome
Yanzong Yang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Loss-of-function mutation of the SCN3B-encoded sodium channel beta 3 subunit associated with a case of idiopathic ventricular fibrillation
Carmen R. Valdivia et al.
CARDIOVASCULAR RESEARCH (2010)
Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25
Steven A. Lubitz et al.
CIRCULATION (2010)
Left-to-Right Atrial Inward Rectifier Potassium Current Gradients in Patients With Paroxysmal Versus Chronic Atrial Fibrillation
Niels Voigt et al.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2010)
Sudden infant death syndrome-associated mutations in the sodium channel beta subunits
Bi-Hua Tan et al.
HEART RHYTHM (2010)
Gain-of-function mutation S422L in the KCNJ8-encoded cardiac KATP channel Kir6.1 as a pathogenic substrate for J-wave syndromes
Argelia Medeiros-Domingo et al.
HEART RHYTHM (2010)
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death
Elena Burashnikov et al.
HEART RHYTHM (2010)
A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
Thomas J. Hund et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Cardiac strong inward rectifier potassium channels
Justus M. B. Anumonwo et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology
Hugues Abriel
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both
Ricardo Caballero et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)
Self-sufficient control of urate homeostasis in mice by a synthetic circuit
Christian Kemmer et al.
NATURE BIOTECHNOLOGY (2010)
Several common variants modulate heart rate, PR interval and QRS duration
Hilma Holm et al.
NATURE GENETICS (2010)
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Nona Sotoodehnia et al.
NATURE GENETICS (2010)
Genome-wide association study of PR interval
Arne Pfeufer et al.
NATURE GENETICS (2010)
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hiroshi Hibino et al.
PHYSIOLOGICAL REVIEWS (2010)
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
Ricardo Caballero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification
Jun Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
MinK-dependent internalization of the I-Ks potassium channel
Xianghua Xu et al.
CARDIOVASCULAR RESEARCH (2009)
Gene Expression Profiling of the Forming Atrioventricular Node Using a Novel Tbx3-Based Node-Specific Transgenic Reporter
Thomas Horsthuis et al.
CIRCULATION RESEARCH (2009)
Cardiac Ion Channels
Augustus O. Grant
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2009)
Protein Kinase A-Dependent Biophysical Phenotype for V227F-KCNJ2 Mutation in Catecholaminergic Polymorphic Ventricular Tachycardia
Amanda L. Vega et al.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2009)
Mutations in Sodium Channel beta 1-and beta 2-Subunits Associated With Atrial Fibrillation
Hiroshi Watanabe et al.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2009)
A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype
Dan Hu et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2009)
IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation
Juan Tamargo et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice
Ross A. Breckenridge et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
Daniel F. Gudbjartsson et al.
NATURE GENETICS (2009)
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
Emelia J. Benjamin et al.
NATURE GENETICS (2009)
NF-kappa B-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II
Lijuan L. Shang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
Genomic structure, transcriptional control, and tissue distribution of HERG1 and KCNQ1 genes
Xiaobin Luo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Genetic insights into normal and abnormal heart development
Mona Nemer
CARDIOVASCULAR PATHOLOGY (2008)
Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43
Kees-Jan Boogerd et al.
CARDIOVASCULAR RESEARCH (2008)
KCNE3 mutation V17M identified in a patient with lone atrial fibrillation
Alicia Lundby et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)
Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolism
Pierre Philip-Couderc et al.
CIRCULATION RESEARCH (2008)
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
Laura E. Briggs et al.
CIRCULATION RESEARCH (2008)
Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome
Eva Delpon et al.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2008)
A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation
Takeru Makiyama et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)
Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a
Michael Hesse et al.
CARDIOVASCULAR RESEARCH (2007)
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson et al.
NATURE (2007)
Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
Nathalie Gaborit et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
SCN4B-encoded sodium channel β4 subunit in congenital long-QT syndrome
Argelia Medeiros-Domingo et al.
CIRCULATION (2007)
Molecular pathway for the localized formation of the sinoatrial node
Mathilda T. M. Mommersteeg et al.
CIRCULATION RESEARCH (2007)
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-Segment elevation, short QT intervals, and sudden cardiac death
Charles Antzelevitch et al.
CIRCULATION (2007)
Characterization of the cardiac KCNE1 gene promoter
Zenab Mustapha et al.
CARDIOVASCULAR RESEARCH (2007)
Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart
Yan Wang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation
Timothy M. Olson et al.
HUMAN MOLECULAR GENETICS (2006)
The cAMP response element binding protein modulates expression of the transient outward current: Implications for cardiac memory
KW Patberg et al.
CARDIOVASCULAR RESEARCH (2005)
The homeodomain transcription factor lrx5 establishes the mouse cardiac ventricular repolarization gradient
DL Costantini et al.
CELL (2005)
Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization
JR Ehrlich et al.
CARDIOVASCULAR RESEARCH (2005)
A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation
M Xia et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
L Dupays et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)
Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
DN Arnosti et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization
E Delpón et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
Tandem promoters and developmentally regulated 5′- and 3′-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel
LJL Shang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pharmacology of cardiac potassium channels
J Tamargo et al.
CARDIOVASCULAR RESEARCH (2004)
Sudden death associated with short-QT syndrome linked to mutations in HERG
R Brugada et al.
CIRCULATION (2004)
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination
MX van Bemmelen et al.
CIRCULATION RESEARCH (2004)
The T-box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system
IPG Moskowitz et al.
DEVELOPMENT (2004)
Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5
VLF Linhares et al.
CARDIOVASCULAR RESEARCH (2004)
Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation
YQ Yang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Mutation in the KCNQ1 gene leading to the short QT-interval syndrome
C Bellocq et al.
CIRCULATION (2004)
Cav1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
I Splawski et al.
CELL (2004)
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)
DW Benson et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
KCNQ1 gain-of-function mutation in familial atrial fibrillation
YH Chen et al.
SCIENCE (2003)
A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current.: Is MiRP1 the missing link?
M Weerapura et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family
F Kyndt et al.
CIRCULATION (2001)
De novo mutation in the SCN5A gene associated with early onset of sudden infant death
H Wedekind et al.
CIRCULATION (2001)
Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
TK Ghosh et al.
HUMAN MOLECULAR GENETICS (2001)
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
Y Hiroi et al.
NATURE GENETICS (2001)
Patterning the embryonic heart:: Identification of five mouse Iroquois homeobox genes in the developing heart
VM Christoffels et al.
DEVELOPMENTAL BIOLOGY (2000)
Chamber formation and morphogenesis in the developing mammalian heart
VM Christoffels et al.
DEVELOPMENTAL BIOLOGY (2000)
Expression of distinct ERG proteins in rat, mouse, and human heart -: Relation to functional IKr channels
AL Pond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)