4.6 Article

Rspondin-1 contributes to the progression and stemness of gastric cancer by LGR5

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Expression of R-Spondin 1 in ApcMin/+ Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling

Marianne Lahde et al.

Summary: Expression of RSPO1 in ApcMin/thorn mice increases apoptosis and reduces proliferation and Wnt signaling in adenoma cells, resulting in development of fewer and smaller intestinal tumors and longer mouse survival.

GASTROENTEROLOGY (2021)

Article Cell Biology

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Wei Wang et al.

Summary: Understanding the genetic and epigenetic factors of cellular senescence is crucial for developing interventions to slow aging. CRISPR-Cas9-based screens identified genes like KAT7 that alleviate senescence in accelerated aging models, and lentiviral vectors encoding Cas9/sg-Kat7 were effective in alleviating cellular aging and extending lifespan.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Gastric cancer: a comprehensive review of current and future treatment strategies

Rachel E. Sexton et al.

CANCER AND METASTASIS REVIEWS (2020)

Article Medicine, General & Internal

Gastric cancer

Elizabeth C Smyth et al.

LANCET (2020)

Article Biochemistry & Molecular Biology

Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases

Soohyun Park et al.

SCIENCE SIGNALING (2020)

Review Oncology

Updates on Management of Gastric Cancer

Fabian M. Johnston et al.

CURRENT ONCOLOGY REPORTS (2019)

Article Multidisciplinary Sciences

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Venkata Naga Srikanth Garikipati et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

The Role of Wnt and R-spondin in the Stomach During Health and Disease

Anne-Sophie Fischer et al.

BIOMEDICINES (2019)

Article Oncology

Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1

Franziska Wilhelm et al.

MOLECULAR CANCER RESEARCH (2017)

Article Cell Biology

LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer

Hao-Zhe Cao et al.

CELL DEATH & DISEASE (2017)

Article Multidisciplinary Sciences

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

Alex Gregorieff et al.

NATURE (2015)

Review Cell Biology

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Wim de Lau et al.

GENES & DEVELOPMENT (2014)

Article Cell Biology

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia

Annie Ng et al.

NATURE CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Meritxell Huch et al.

EMBO JOURNAL (2013)

Article Multidisciplinary Sciences

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch et al.

NATURE (2013)

Article Multidisciplinary Sciences

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao et al.

NATURE (2012)

Article Multidisciplinary Sciences

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

Arnout G. Schepers et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau et al.

NATURE (2011)

Article Multidisciplinary Sciences

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker et al.

NATURE (2007)