Structural insights into ORF10 recognition by ZYG11B

Article Immunology

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

Xingyu Li et al.

Summary: The study reveals a novel mechanism by which ORF10 of SARS-CoV-2 inhibits the innate immune response through inducing mitophagy-mediated MAVS degradation.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

Sk. Sarif Hassan et al.

Summary: The article highlights the potential impact of single and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants on the severity of the virus and its associated consequences.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Medicine, Research & Experimental

SARS-CoV-2 Proteins: Are They Useful as Targets for COVID-19 Drugs and Vaccines?

Mohammed Elimam Ahamed Mohammed

Summary: The proteins of coronavirus are classified into non-structural, structural, and accessory types, each with different functions. The functions and structures of SARS-CoV-2 proteins are not fully understood yet, but they can be potential targets for COVID-19 drugs and vaccines. Vaccines and monoclonal antibodies targeting spike proteins have been approved and used for COVID-19 prevention and treatment.

CURRENT MOLECULAR MEDICINE (2022)

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Article Immunology

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?

Lok-Yin Roy Wong et al.

Summary: Human coronaviruses can cause a wide range of diseases, with severe cases characterized by dysregulated host immune responses and active viral interference. The severity of disease is mainly determined by host immune responses and viral interference.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Pandemic analysis of infection and death correlated with genomic open reading frame 10 mutation in severe acute respiratory syndrome coronavirus 2 victims

De-Ming Yang et al.

Summary: The study analyzed mutations in the Orf10 protein of SARS-CoV-2 patients, finding varying mutation rates in different regions, with higher rates in A8 and V30. The numbers of COVID-19 patients are correlated to the death numbers, but not with the death rates, and the A8, I13, and V30 sites in the Orf10 sequence show high mutation rates.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

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Article Multidisciplinary Sciences

ORF10?Cullin-2?ZYG11B complex is not required for SARS-CoV-2 infection

Elijah L. Mena et al.

Summary: The study found an interaction between ORF10 and CRL2ZYG11B but no evidence that ORF10 is functioning to inhibit or hijack CRL2ZYG11B.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biochemistry & Molecular Biology

Molecular basis for recognitionof Gly/N-degrons by CRL2ZYG11B and CRL2ZER1

Xiaojie Yan et al.

Summary: The study presents crystal structures of ZYG11B and ZER1 bound to various Gly/N-degrons, revealing how they use ARM repeats to engage the first four residues of Gly/N-degrons. The structures show that the Gly/N-degron is specifically recognized by ZYG11B and ZER1 through conserved hydrogen bonds, providing important information for future structure-based chemical probe design.

MOLECULAR CELL (2021)

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Review Immunology

SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns

Natalia Redondo et al.

Summary: This article summarizes the current knowledge of SARS-CoV-2 accessory proteins, highlighting their roles during infection and impact on the host immune response.

FRONTIERS IN IMMUNOLOGY (2021)

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Editorial Material Medicine, General & Internal