4.6 Article

Overexpressed COL3A1 has prognostic value in human esophageal squamous cell carcinoma and promotes the aggressiveness of esophageal squamous cell carcinoma by activating the NF-kB pathway

Related references

Note: Only part of the references are listed.
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

Yang Chen et al.

Summary: The stromal desmoplastic reaction in pancreatic ductal adenocarcinoma involves significant accumulation of type I collagen (Col1). Deletion of Col1 specifically in myofibroblasts accelerates PDAC progression by increasing Cxcl5 expression in cancer cells and promoting recruitment of myeloid-derived suppressor cells. Targeting CXCR2 and CCR2 may help restrain accelerated PDAC progression in the absence of stromal Col1.

CANCER CELL (2021)

Review Oncology

Collagen Type XI Alpha 1 (COL11A1): A Novel Biomarker and a Key Player in Cancer

Sameera Nallanthighal et al.

Summary: COL11A1 is not only increased in cancers, but high levels are associated with poor clinical outcomes, promoting tumor cell aggressiveness through multiple mechanisms. This review discusses the biological functions of COL11A1 in cancer and highlights its role as a promising biomarker and key player in cancer.

CANCERS (2021)

Article Cell Biology

FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis

Hong-Qing Cai et al.

Summary: FKBP10 is highly expressed in glioma and promotes cell proliferation by interacting with Hsp47 and activating the AKT-CREB-PCNA signaling pathways. Inhibition of FKBP10 related signaling may offer a potential therapeutic option for glioma patients.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

Editorial Material Medicine, General & Internal

Oesophageal cancer: risks, prevention, and diagnosis

Sri G. Thrumurthy et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

Review Medicine, Research & Experimental

The role of collagen in cancer: from bench to bedside

Shuaishuai Xu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Article Gastroenterology & Hepatology

The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma

Yu-Shang Yang et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Epidemiology of Esophageal Squamous Cell Carcinoma

Christian C. Abnet et al.

GASTROENTEROLOGY (2018)

Article Cell Biology

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

Andriy O. Samokhin et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Oncology

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis

Sai Ma et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Oncology

Worldwide incidence, mortality and time trends for cancer of the oesophagus

Bhawna Gupta et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2017)

Review Medicine, General & Internal

Oesophageal cancer

Jesper Lagergren et al.

LANCET (2017)

Article Cell Biology

Dynamic interplay between the collagen scaffold and tumor evolution

Mikala Egeblad et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections

Seung-Tae Lee et al.

HEART AND VESSELS (2008)

Article Biochemistry & Molecular Biology

Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen

GA Di Lullo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)