Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 431, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2022.113961
Keywords
Attentional set-shifting task; D-cycloserine; Cognitive flexibility; Rats; Scopolamine; Schizophrenia
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Funding
- DAAD scholarship (German Academic Exchange Service) [57552335]
- DFG (German Research Foundation) [SFB 1436/A1, 425899996]
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This study aimed to investigate the effects of D-cycloserine on cognitive flexibility in rats. The results showed that D-cycloserine improved cognitive flexibility measured by the ASST.
Cognitive flexibility facilitates adaptions to a changing environment in humans and animals and can be assessed with the attentional set shifting task (ASST). In various learning paradigms for laboratory rodents, the partial NMDA receptor agonist D-cycloserine has been found to have pro-cognitive effects. However, D-cycloserine has not yet been investigated for its effects on cognitive flexibility. The aim of the present study was to determine whether D-cycloserine is able to improve cognitive flexibility measured by the ASST in rats. Rats were first pretreated with the muscarinic antagonist scopolamine (0.5 mg/kg) before the D-cycloserine administrations (20 mg/kg) to induce deficits in ASST performance. Our findings showed impaired ASST performance after scopolamine administration with significant effects on reversal phases and extra-dimensional shift. D-cycloserine treatment selectively improved the performance in the extra-dimensional shift and the last reversal phase, where scopolamine effects were most pronounced. These findings suggest that D-cycloserine can rescue deficits in cognitive flexibility.
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