Journal
AVIAN PATHOLOGY
Volume 51, Issue 6, Pages 550-560Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03079457.2022.2103396
Keywords
Mycoplasma gallisepticum; vaccination; tracheal lesions; air sac lesions; poultry; lesion scores
Categories
Funding
- Australian Research Council [LP160101105]
- Bioproperties Pty. Ltd.
- Australian Research Council [LP160101105] Funding Source: Australian Research Council
Ask authors/readers for more resources
This study reviewed the literature on the evaluation of vaccine efficacy against pathological changes caused by M. gallisepticum in poultry. The study found that assessment of tracheal lesions is a more reliable method for evaluating disease induced by M. gallisepticum compared to assessment of air sac lesions. Furthermore, the study highlighted the importance of using a standardized model for evaluation and reporting of M. gallisepticum vaccines.
Mycoplasma gallisepticum is the primary causative agent of chronic respiratory disease in poultry, and vaccination is the measure most commonly used for its control. Pathological changes caused by M. gallisepticum are mainly observed in the trachea and air sacs, but assessment of air sac lesions is subjective. Standardized parameters for evaluation of pathological changes, and their reproducibility and discrimination in uninfected and infected groups, are critical when assessing the efficacy of M. gallisepticum vaccination. This study reviewed and critically appraised the published literature on evaluation of vaccine efficacy against pathological changes caused by M. gallisepticum in poultry in the trachea and air sacs. A search of four electronic databases, with subsequent manual filtering, identified 23 eligible papers published since 1962 describing the assessment of histopathological changes in the trachea using tracheal lesion scores and/or measurement of tracheal mucosal thicknesses and assessment of gross air sac lesions using lesion scores. Measurement of tracheal lesions proved a more reliable and robust method of assessing disease induced by M. gallisepticum when compared to assessment of air sac lesions, highlighting the importance of including assessment of tracheal lesions as the primary outcome variable in vaccine efficacy studies. In addition, this study also identified the necessity for use of a standardized model for evaluation and reporting on M. gallisepticum vaccines to minimize variations between vaccine efficacy studies and to allow direct comparisons between them.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available