Journal
AUTOPHAGY
Volume 19, Issue 2, Pages 731-733Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2022.2100617
Keywords
Antiviral target; autophagy; coronavirus; CRISPR screen; host factor
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A recent study identified host dependency factors, including immunophilins FKBP8, TMEM41B, and MINAR1, which regulate the macroautophagy/autophagy pathway and play crucial roles in the lifecycle of coronaviruses such as SARS-CoV, MERS-CoV, and SARS-CoV-2. These factors could potentially serve as therapeutic targets for the treatment of these emerging coronaviruses.
The recurrence of zoonotic transmission events highlights the need for novel treatment strategies against emerging coronaviruses (CoVs), namely SARS-CoV, MERS-CoV and most notably SARS-CoV-2. Our recently performed genome-wide CRISPR knockout screen revealed a list of conserved pan-coronavirus as well as MERS-CoV or HCoV-229E-specific host dependency factors (HDF) essential during the viral life cycle. Intriguingly, we identified the macroautophagy/autophagy pathway-regulating immunophilins FKBP8, TMEM41B, and MINAR1 as conserved MERS-CoV, HCoV-229E, SARS-CoV, and SARS-CoV-2 host factors, which further constitute potential targets for therapeutic intervention by clinically approved drugs.
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