Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 45, Issue 6, Pages 367-389Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-022-01393-3
Keywords
Astragalus polysaccharide; Immune regulation; Immune organs; Immune cells; Anticancer
Categories
Funding
- Sichuan Provincial Administration of Traditional Chinese Medicine [2018QN019]
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This review provides a comprehensive overview of the research progress on the immunomodulatory effect of Astragalus polysaccharide. It summarizes the effects of Astragalus polysaccharide on central and peripheral immune organs, as well as various immune cells. Astragalus polysaccharide shows promising potential for the treatment of diseases, particularly in the field of cancer.
The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus. This review aims to provide a comprehensive overview of the research progress on the immunomodulatory effect of Astragalus polysaccharide and provide valuable reference information. We review the immunomodulatory effect of Astragalus polysaccharide on central and peripheral immune organs, including bone marrow, thymus, lymph nodes, spleen, and mucosal tissues. Furthermore, the immunomodulatory effect of Astragalus polysaccharide on a variety of immune cells is summarized. Studies have shown that Astragalus polysaccharide can promote the activities of macrophages, natural killer cells, dendritic cells, T lymphocytes, B lymphocytes and microglia and induce the expression of a variety of cytokines and chemokines. The immunomodulatory effect of Astragalus polysaccharide makes it promising for the treatment of many diseases, including cancer, infection, type 1 diabetes, asthma, and autoimmune disease. Among them, the anticancer effect is the most prominent. In short, Astragalus polysaccharide is a valuable immunomodulatory medicine, but further high-quality studies are warranted to corroborate its clinical efficacy.
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