Celebration of a century of insulin therapy in children with type 1 diabetes

Editorial Material Endocrinology & Metabolism

Racial and Socioeconomic Disparities in Pediatric Type 1 Diabetes: Time for a Paradigm Shift in Approach

Terri H. Lipman et al.

DIABETES CARE (2021)

Article Chemistry, Medicinal

Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Thomas B. Kjeldsen et al.

Summary: The molecular engineering of insulin icodec has resulted in a plasma half-life of 196 hours in humans, suitable for once-weekly subcutaneous administration. In a phase-2 clinical trial, it demonstrated safe and efficacious glycemic control comparable to once-daily insulin glargine in type 2 diabetes patients, showing the potential of insulin icodec as a long-acting therapeutic option.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Multidisciplinary Sciences

Strategies for durable β cell replacement in type 1 diabetes

Todd M. Brusko et al.

Summary: Advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for individuals with type 1 diabetes, but still fall short of the metabolic control provided by native islets. Integrated advancements in islet cell replacement and immunomodulatory therapies are offering hope for the restoration of endogenous glucose regulation. Progress in stem cell biology and graft site design are providing innovative sources for cellular material and improved engraftment.

SCIENCE (2021)

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Review Multidisciplinary Sciences

Type 1 diabetes glycemic management: Insulin therapy, glucose monitoring, and automation

Bruce A. Perkins et al.

Summary: Despite innovations in insulin therapy, most type 1 diabetes patients still struggle to achieve sufficient glycemic control. The future may lie in combining pharmacological solutions with automated insulin delivery methods, utilizing machine learning and other technologies to enhance effectiveness.

SCIENCE (2021)

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Review Endocrinology & Metabolism