4.6 Article

CpXCo(III)-catalyzed selective C-H alkenylation of indoles with ethynylethylene carbonates

Journal

APPLIED ORGANOMETALLIC CHEMISTRY
Volume 36, Issue 11, Pages -

Publisher

WILEY
DOI: 10.1002/aoc.6863

Keywords

alkyne insertion; cobalt; C-H alkenylation; indole derivatives; ethynylethylene carbonates

Funding

  1. Natural Science Foundation of Shandong Province [ZR2019BB011]
  2. Scientific Research Foundation of Qingdao University of Science Technology [010029022]

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An efficient and selective C-H functionalization reaction of indoles into ethynylethylene carbonates has been achieved via (CpCo)-Co-X(III) catalysis, allowing the synthesis of various vinylindoles with high yields and regioselectivity.
An efficient and selective insertion of indoles into ethynylethylene carbonates has been achieved via (CpCo)-Co-X(III)-catalyzed C-H functionalization. Compared with a Cp*Co(III) catalyst, the more sterically hindered (CpCo)-Co-X(III) improved the selectivity of rare 1,2-insertion. This protocol provides an approach for synthesizing various vinylindoles in good yields with high regioselectivity.

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