Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-?B/STAT3 Signaling in Non-small-cell Lung Cancer Cells

Background/Aim: Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer worldwide, and treatment outcomes are still poor. Magnolol, a hydroxylated biphenyl isolated from Magnolia officinalis, was found to be effective against hepatocellular carcinoma via inactivating nuclear-factor-kappa B (NF-kappa B) signaling. However, whether magnolol targets not only NF-kappa B but also other factors in NSCLC and may contribute to the suppression of tumor progression is unclear. Materials and Methods: Cell viability, flow cytometry, and western blotting assays were used to identify the mechanism of magnolol action in human lung adenocarcinoma cell lines A549 and CL1-5-F4. Results: Our results indicated that magnolol induced cytotoxicity through extrinsic/intrinsic apoptosis

Automated summary

This study found that magnolol, a hydroxylated biphenyl isolated from Magnolia officinalis, has therapeutic effects on non-small-cell lung cancer (NSCLC) by inactivating NF-kappa B signaling and inducing cytotoxicity.