☆ 4.7 Article

Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways

ANNALS OF THE RHEUMATIC DISEASES (2022)

Related references

Note: Only part of the references are listed.

Review Immunology

Molecular mechanisms controlling age-associated B cells in autoimmunity*

Swati Phalke et al.

Summary: Age-associated B cells (ABCs) play critical roles in the pathogenesis of autoimmune disorders, aging-associated diseases, and infections. They exhibit a distinctive phenotype and express T-bet and CD11c markers, hence known as CD11c(+)T-bet(+) B cells. The formation of ABCs is promoted by specific combinations of innate and adaptive signals.

IMMUNOLOGICAL REVIEWS (2022)

Add to Collection

Review Rheumatology

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach

Yoshiya Tanaka et al.

Summary: This Review discusses the therapeutic use of Janus kinase inhibitors in autoimmune rheumatic diseases, highlighting their disease-specific mechanisms of action. JAK inhibitors suppress intracellular signaling mediated by multiple cytokines, offering potential treatment options for a range of immune and inflammatory disorders.

NATURE REVIEWS RHEUMATOLOGY (2022)

Add to Collection

Article Allergy

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Maria Sokolova et al.

Summary: Autoantibodies such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) are key markers of rheumatoid arthritis (RA) and can impact disease course and progression. The identification of new autoantibodies and advancements in diagnostic techniques have led to a decrease in the seronegative patient population. Autoantibodies not only play a role in the pathogenesis of RA but also directly influence disease progression and radiographic outcomes.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

Add to Collection

Article Rheumatology

Effect of Clonally Expanded PD-1highCXCR5-CD4+Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis

Jonas Fischer et al.

Summary: The study revealed the clonal expansion of CD4+ Tph cells in the joints of ANA-positive JIA patients, particularly promoting the differentiation of CD21(low/-)CD11c+ DN B cells. The expansion of Tph cells and DN B cells may reflect the autoimmune response in the joints of ANA-positive JIA patients.

ARTHRITIS & RHEUMATOLOGY (2022)

Add to Collection

Review Microbiology

Age-associated B cells in viral infection

Isobel C. Mouat et al.

Summary: Age-associated B cells (ABCs) are a unique population of B cells that play both protective and pathogenic roles in the antiviral response. They expand during viral infections and are capable of antibody secretion and T cell activation. ABCs persist after resolution of infection and are crucial for memory and recall responses. Future research should explore the impact of sex on the ABC population and the heterogeneity of ABCs between contexts.

PLOS PATHOGENS (2022)

Add to Collection

Article Rheumatology

Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis

Zhu Chen et al.

Summary: The study revealed that IL-13R alpha 1 plays a crucial role in controlling the generation and differentiation of ABCs. Deficiency of IL-13R alpha 1 reduced the accumulation of ABCs, differentiation into plasmablasts, and autoantibody production, leading to prolonged survival and delayed tissue inflammation.

ARTHRITIS & RHEUMATOLOGY (2022)

Add to Collection

Article Immunology

The expansion of human T-bethighCD21low B cells is T cell dependent

Baerbel Keller et al.

Summary: The accumulation of CD21(low) B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders. The transcription factor T-bet plays a prominent role in the regulation of T-bet(high)CD21(low) B cells, and essential signals such as BCR and IFN gamma R are crucial for the differentiation and expansion of these cells. Identification of important pathways provides potential targets for auto-reactive T-bet(high)CD21(low) B cells in autoimmune conditions.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

Robert W. Maul et al.

Summary: A distinct population of B cells marked by elevated CD11c expression was identified in patients with systemic lupus erythematosus (SLE), exhibiting unique characteristics in gene expression and IgH repertoire composition. These CD11c(hi) B cells showed similarities with some germinal center transcripts but distinct from conventional B cell subsets, suggesting a potential role in autoimmune responses. The findings suggest a potential link between defects in negative selection in germinal centers and the development of autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Autoantibodies in Rheumatoid Arthritis - Laboratory and Clinical Perspectives

Johan Ronnelid et al.

Summary: Measurement of autoantibodies like RF and ACPA is crucial in the diagnosis and treatment of RA, but lack of harmonization between different commercial tests poses a challenge. It is recommended that all RF and ACPA tests should have a diagnostic specificity of 98-99%, and the introduction of test result-specific likelihood ratios can provide more precise information for clinical decision-making. Detection of autoantibodies can also be used to predict future arthritis development and prognosis in at-risk patients.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

B cells as target for immunotherapy in rheumatic diseases - current status

Ewa Bryl

Summary: This mini-review provides a brief overview of various therapeutic strategies targeting B cells in systemic autoimmune rheumatic diseases, including depletion of B cells, depletion of long-lived plasma cells, altering activation of B cells, and inhibiting proteasomes in plasma cells. The past successful and less successful therapies are discussed, along with possible reasons for failures.

IMMUNOLOGY LETTERS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor

Sung-Sik Yoon et al.

Summary: RA-FLSs, activated by TNF-alpha, may promote joint damage through the up-regulation of hVCAM1 and hBAFF, which could influence the interaction between B cells and synovial cells, contributing to the pathogenesis of rheumatoid arthritis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Edd Ricker et al.

Summary: This study demonstrates that age-associated B cells (ABC) play a crucial role in sex-specific autoimmune diseases, particularly in the development of lupus-like syndrome in females. The absence of certain guanine exchange factors in double-knock-out (DKO) mice leads to the accumulation of ABCs, which differentiate into pathogenic effector B cell populations with pro-inflammatory function. The upregulation of Tlr7 in DKO males further enhances the dissemination and pathogenicity of ABCs, resulting in severe pulmonary inflammation and early mortality.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Immunology

Age-Associated B Cells

Michael P. Cancro

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Add to Collection

Article Immunology

Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity

Sathi Babu Chodisetti et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Rheumatology

Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis

Andreea Petrasca et al.

RHEUMATOLOGY (2020)

Add to Collection

Article Cell Biology

Follistatin-like protein 1 induction of matrix metalloproteinase 1, 3 and 13 gene expression in rheumatoid arthritis synoviocytes requires MAPK, JAK/STAT3 and NF-κB pathways

Su Ni et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Article Immunology

Activation of naive CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

Jason P. Twohig et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Challenges in the treatment of Rheumatoid Arthritis

Paola Conigliaro et al.

AUTOIMMUNITY REVIEWS (2019)

Add to Collection

Review Immunology

T-cells interact with B cells, dendritic cells, and fibroblast-like synoviocytes as hub-like key cells in rheumatoid arthritis

Xiao-Xi Hu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Add to Collection

Article Immunology

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Fan Zhang et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes

Hiroyuki Yoshitomi

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus

Wenqian Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Immunology

The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation

Irun R. Cohen et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

Alexandra Bocharnikov et al.

JCI INSIGHT (2019)

Add to Collection

Review Immunology

Consequences of B-cell-depleting therapy: hypogammaglobulinemia and impaired B-cell reconstitution

Keith A. Sacco et al.

IMMUNOTHERAPY (2018)

Add to Collection

Article Immunology

Regulation of age-associated B cells by IRF5 in systemic autoimmunity

Michela Manni et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Shu Wang et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Immunology

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Scott A. Jenks et al.

IMMUNITY (2018)

Add to Collection

Article Medicine, Research & Experimental

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Kira Rubtsova et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Add to Collection

Article Multidisciplinary Sciences

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Deepak A. Rao et al.

NATURE (2017)

Add to Collection

Review Immunology

Arthritis models: usefulness and interpretation

Natacha Bessis et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Add to Collection

Article Immunology

Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation

Denise Lau et al.

SCIENCE IMMUNOLOGY (2017)

Add to Collection

Article Rheumatology

T-bet+ CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Ya Liu et al.

ARTHRITIS RESEARCH & THERAPY (2017)

Add to Collection

Article Immunology

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

Phillip P. Domeier et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Add to Collection

Article Immunology

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

Martin S. Naradikian et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Immunology

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

Nele Claes et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Immunology

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

Christopher M. Tipton et al.

NATURE IMMUNOLOGY (2015)

Add to Collection

Article Rheumatology

Expansion of Autoreactive Unresponsive CD21/low B Cells in Sjogren's SyndromeAssociated Lymphoproliferation

D. Saadoun et al.

ARTHRITIS AND RHEUMATISM (2013)

Add to Collection

Article Multidisciplinary Sciences

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

Kira Rubtsova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Add to Collection

Article Rheumatology

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

Sanna Rosengren et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

Add to Collection

Article Hematology

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Yi Hao et al.

BLOOD (2011)

Add to Collection

Article Hematology

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Anatoly V. Rubtsov et al.

BLOOD (2011)

Add to Collection

© Peeref 2019-2024. All rights reserved.