4.5 Review

Treatment for relapsed acute promyelocytic leukemia

Related references

Note: Only part of the references are listed.
Article Biophysics

Autologous hematopoietic cell transplantation during second or subsequent complete remission of acute promyelocytic leukemia: a prognostic factor analysis

Masamitsu Yanada et al.

Summary: Autologous hematopoietic cell transplantation is effective for patients with relapsed acute promyelocytic leukemia, with very favorable long-term results when conducted during CR2+. Other factors such as age, disease status, and MRD status did not predict survival outcomes.

BONE MARROW TRANSPLANTATION (2022)

Article Biophysics

Hematopoietic stem cell transplantation for adults with relapsed acute promyelocytic leukemia in second complete remission

Jaime Sanz et al.

Summary: The study compared outcomes of adult patients with APL in CR2 receiving alloHSCT or autoHSCT, showing higher non-relapse mortality in the alloHSCT group but no significant difference in relapse rate. AutoHSCT resulted in better Leukemia-free survival (LFS) and overall survival (OS) compared to alloHSCT, mainly due to reduced non-relapse mortality.

BONE MARROW TRANSPLANTATION (2021)

Article Hematology

Management of relapse in acute promyelocytic leukaemia treated with up-front arsenic trioxide-based regimens

N. A. Fouzia et al.

Summary: The study showed that in relapsed APL patients, obtaining a second molecular remission after salvage therapy was more common. Autologous stem cell transplant was found to be an effective option for patients achieving MR, leading to improved long-term survival rates.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Review Biophysics

The evolving concept of indications for allogeneic hematopoietic cell transplantation during first complete remission of acute myeloid leukemia

Masamitsu Yanada

Summary: The longstanding debate regarding allogeneic HCT for AML patients in CR1 remains unsettled, but advancements in understanding disease molecular pathogenesis and transplantation practices are continuously evolving the indications for this treatment approach.

BONE MARROW TRANSPLANTATION (2021)

Article Hematology

Mutational landscape of patients with acute promyelocytic leukemia at diagnosis and relapse

Licia Iaccarino et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Review Hematology

Current standard treatment of adult acute promyelocytic leukaemia

Francesco Lo-Coco et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

Article Biophysics

Autologous transplant remains the preferred therapy for relapsed APL in CR2

C. Ganzel et al.

BONE MARROW TRANSPLANTATION (2016)

Article Hematology

Autologous Is Superior to Allogeneic Hematopoietic Cell Transplantation for Acute Promyelocytic Leukemia in Second Complete Remission

Jennifer L. Holter Chakrabarty et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2014)

Letter Medicine, General & Internal

Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia

Hong-Hu Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

F. Lo-Coco et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Oncology

Arsenic-induced APL differentiation in cerebrospinal fluid

Annett Helwig et al.

LEUKEMIA RESEARCH (2007)