Radical Brook Rearrangements: Concept and Recent Developments

The Brook rearrangement has already become established as one of the most important molecular rearrangements in synthetic chemistry and has been applied in the generation of complexes, drug discovery, material science, and natural products synthesis. Compared to the widely known ionic mechanism, the radical Brook rearrangement is less explored because of the difficulty in generating alkoxyl radical species. This Minireview summarizes the early developments and general concept of the radical Brook rearrangement and highlights recent advances in photocatalytic reactions and transition-metal-catalyzed cross-coupling reactions involving radical Brook rearrangements. We hope this survey will inspire further developments in this emerging area.

Automated summary

The Brook rearrangement is an important molecular rearrangement in synthetic chemistry that has applications in the generation of complexes, drug discovery, material science, and natural products synthesis. While the radical Brook rearrangement has received less attention compared to the widely known ionic mechanism, recent advances in photocatalytic reactions and transition-metal-catalyzed cross-coupling reactions have contributed to its exploration.