Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 34, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202205266
Keywords
Coacervates; Light-Activation; Multi-Compartments; Polymersomes; Synthetic Cells
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Funding
- Alexander von Humboldt Foundation [3.5-CHN-1222717-HFST-P]
- Federal Ministry of Education and Research of Germany (BMBF)
- Max Planck Society
- Projekt DEAL
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In this study, giant polymersomes equipped with spiropyran-based permeability modulators were designed. Photo-isomerization of the modulators increased the permeability of the polymer membrane. These photoactivated polymersomes were used to construct two cell-like systems controlled by light-activated transport of hydrophilic molecules.
Giant polymersomes are versatile and stable biomimetic compartments that are ideal for building cell-like systems. However, the transport of hydrophilic molecules across the membrane, which controls the function of cell-like systems, is limited by the low permeability of polymeric bilayers. Therefore, mechanisms to control the permeability of polymersomes are necessary to create functional cell-like systems. Here, we describe the design of giant polymersomes equipped with spiropyran-based permeability modulators. Photo-isomerization of the modulators leads to perturbation of the polymer membrane, resulting in increased permeability. The photoactivated polymersomes were used to construct two cell-like systems controlled by light-activated transport of hydrophilic molecules. First, we designed an enzymatic micro-reactor activated by light irradiation. Second, we constructed a hybrid coacervate-in-polymersome system that mimics the adaptive formation of biological condensates in cells.
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