Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202206293
Keywords
Cocrystals; Crystal Engineering; Green Chemistry; Mechanochemistry; Solid-State Chemistry
Categories
Ask authors/readers for more resources
This study presents a rapid blending technology called SpeedMixing for fast mechanosynthesis and discovery of model pharmaceutical cocrystals. The method utilizes rapid spinning in the absence of bulk solvents and milling/grinding media. Syntheses of pharmaceutical cocrystals based on different active pharmaceutical ingredients demonstrate that SpeedMixing is a rapid, scalable, controllable, and selective method for the synthesis of cocrystals, cocrystal polymorphs, and stoichiomorphs.
We present SpeedMixing, a rapid blending technology, as an approach for fast mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid spinning in the absence of bulk solvents and milling/grinding media. Syntheses of pharmaceutical cocrystals based on the active pharmaceutical ingredients (APIs) carbamazepine, dihydrocarbamazepine, and nicotinamide demonstrate SpeedMixing as a method for rapid, scalable, as well as controllable and selective synthesis of cocrystals, cocrystal polymorphs and stoichiomorphs, including the discovery of an unexpected methanol solvate of the archetypal cocrystal of carbamazepine and saccharin, which has eluded extensive screens over 20 years.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available