Molecular mechanism behind methamphetamine-induced damages in testicular tissue: Evidences for oxidative stress, autophagy, and apoptosis

Article Toxicology

Down-regulation of CatSper 1 and CatSper 2 genes by methamphetamine

Somaieh Mansouri et al.

Summary: The study found that METH damages the male reproductive system through the oxidative stress pathway and by reducing the expression of CatSper1, 2 genes and proteins.

TOXIN REVIEWS (2022)

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Article Genetics & Heredity

Different continuous exercise training intensities induced effect on sertoli-germ cells metabolic interaction; implication on GLUT-1, GLUT-3 and MCT-4 transporting proteins expression level

Poupak Soudmand et al.

Summary: Low and moderate-intensity exercise training did not significantly affect the expression levels of metabolic substrates transmembrane transporters in testicular tissue, while high-intensity training led to suppression of protein contents of GLUT-1, GLUT-3, and MCT-4 in SCs and reduced SCs survival, resulting in failed spermatogenesis and spermiogenesis.

GENE (2021)

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Article Cell Biology

Cytoskeleton integrity influences XRCC1 and PCNA dynamics at DNA damage

Verena Hurst et al.

Summary: DNA damage induced by 405-nm laser light recruits proteins involved in base excision repair (BER), but perturbing actin or tubulin polymerization in human cells alters the dynamics of BER factors. Depolymerization of cytoplasmic actin may compromise BER efficiency in mammals due to increased levels of nuclear actin and tubulin, linking cytoskeletal integrity to BER.

MOLECULAR BIOLOGY OF THE CELL (2021)

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Review Biochemistry & Molecular Biology

Detection of Genomic Uracil Patterns

Angela Bekesi et al.

Summary: The appearance of uracil in DNA is a common genomic modification, with three different routes of formation, two of which do not require specific enzymes. Efficient uracil-DNA detection methods are crucial to understanding the potential roles of genomic uracil.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Role of Oxidative DNA Damage and Repair in Atrial Fibrillation and Ischemic Heart Disease

Liangyu Hu et al.

Summary: Atrial fibrillation (AF) and ischemic heart disease (IHD) are common cardiac diseases with significant impact on cardiovascular health. Oxidative DNA damage may play a major role in promoting the development of these diseases, with antioxidants and DNA repair enzymes being potential therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

High-fat diet-induced obesity amplifies HSP70-2a and HSP90 expression in testicular tissue; correlation with proliferating cell nuclear antigen (PCNA)

Masoumeh Moradi-Ozarlou et al.

Summary: The study found that obese rats induced by HFD showed a significant increase in mRNA levels of Hsp70-2a and Hsp90, while the mRNA levels of PCNA and the percentage of PCNA+ cells were decreased in the obese group. Additionally, obesity led to a significant decrease in testicular TAC, resulting in a reduction in serum testosterone levels, along with cell DNA and RNA damage.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

ROS and metabolomics-mediated autophagy in rat's testicular tissue alter after exercise training; Evidence for exercise intensity and outcomes

Samaneh Akbar Gharehbagh et al.

Summary: Exercise training has significant impacts on testicular antioxidant and metabolic potentials. High-intensity training can suppress antioxidant biomarkers while increasing autophagy-inducers expression, while low and moderate intensity training may help maintain metabolic homeostasis and promote spermatogenesis differentiation.

LIFE SCIENCES (2021)

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Article Cell Biology