Journal
ANALYTICAL SCIENCES
Volume 38, Issue 10, Pages 1297-1304Publisher
SPRINGERNATURE
DOI: 10.1007/s44211-022-00160-0
Keywords
Nitric Oxide (NO); Electrocatalysts; Composite carbon materials; Endothelial cells; Spheroids
Categories
Funding
- JST COI [JPMJCE1303]
- Japan Society for the Promotion of Science (JSPS) [18H01840, 18H01999, 21H01957, 21H03803]
- System Design of Inclusive Society Living with Infectious Diseases (SDGS-ID), Tohoku University
- Shimadzu Science Foundation
- Kato Foundation for Promotion for Science
- Murata Science Foundation
- Electrochemical Society of Japan
- Japan Association for Chemical Innovation
- KAKENHI programs [20K15374]
- [20J21401]
Ask authors/readers for more resources
Endothelial cells are commonly used for vascular biology studies. Recent advancements in tissue engineering have enabled the development of three-dimensional culture systems for vascular endothelial cells, which can serve as physiologically relevant models. To facilitate research, an electrochemical device has been developed for detecting nitric oxide (NO), a crucial molecule in the vasculature, to evaluate endothelial cells cultured in a 3D environment.
Endothelial cells have been widely used for vascular biology studies; recent progress in tissue engineering have offered three-dimensional (3D) culture systems for vascular endothelial cells which can be considered as physiologically relevant models. To facilitate the studies, we developed an electrochemical device to detect nitric oxide (NO), a key molecule in the vasculature, for the evaluation of 3D cultured endothelial cells. Using an NO-sensitive catalyst composed of Fe-N co-doped reduced graphene oxide, the real-time monitoring of NO release from the endothelial cell spheroids was demonstrated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available