Voltage-Gated Sodium Channel NaV1.8 Dysregulates Na and Ca, Leading to Arrhythmias in Patients with Sleep-Disordered Breathing

Article Critical Care Medicine

Multinight Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea

Bastien Lechat et al.

Summary: Recent studies suggest that the severity of obstructive sleep apnea (OSA) can vary significantly from night to night, which has important implications for diagnosis and management. This study used a novel under-mattress sleep analyzer to assess OSA prevalence from multinight in-home recordings in a large community sample. The findings reveal a global prevalence of moderate to severe OSA of approximately 20%, and approximately 20% of people diagnosed with a single-night study may be misclassified. These findings emphasize the importance of considering night-to-night variation in OSA diagnosis and management.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Increased NaV1.8 expression in patients with sleep-disordered breathing induces pro-arrhythmic activity

S Lebek et al.

EUROPEAN HEART JOURNAL (2021)

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Article Critical Care Medicine

Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea A Randomized Controlled Trial

Gunn Marit Traaen et al.

Summary: Treatment with CPAP did not lead to a statistically significant reduction in AF burden in patients with paroxysmal AF and SA.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease

Andrey Zinchuk et al.

Summary: This study found that a low ArTH, as well as very low and high <(V)over dot> comp, are associated with worse long-term CPAP adherence in patients with CAD and OSA. Physiological traits, along with established determinants, may help predict and improve CPAP adherence.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems