Correlations of Full-Field Stimulus Threshold With Functional and Anatomical Outcome Measurements in Advanced Retinitis Pigmentosa

center dot PURPOSE: To compare full-field stimulus (FST) thresh-old values to conventional functional and anatomical measures commonly used in clinical practice. center dot DESIGN: Cross-sectional study. center dot METHODS: Patients with retinitis pigmentosa with non -detectable electroretinogram rod-mediated responses and light-adapted 3.0 cd center dot s center dot m2 30-Hz flicker (LA 3.0 flicker) amplitudes of 15 mV or less were included in this study. The threshold values for blue, white, and red stimuli on FST were correlated with best-corrected visual acu-ity, LA 3.0 flicker amplitude and implicit times, length of the ellipsoid zone (EZ) band and thickness of outer nuclear layer measurements on optical coherence tomog-raphy, and the vertical and horizontal diameters of the autofluorescent ring on autofluorescence imaging. center dot RESULTS: Forty-two eyes of 21 patients were included in the study. The mean FST thresholds were-22.5 +/- 15.5 dB,-17.6 +/- 11.5 dB, and-12.7 +/- 6.0 dB for the blue, white, and red stimuli, respectively. The threshold values for the 3 FST stimuli were significantly correlated with selected functional and anatomical outcome mea-sures. Specifically, they were strongly correlated with LA 3.0 flicker amplitude and EZ band length measured on optical coherence tomography. Using linear regression, blue and white stimulus values on FST were found to be predictive of EZ band length (R 2 = 0.579 and 0.491, respectively), and the vertical (R 2 = 0.694 and 0.532, respectively) and horizontal (R 2 = 0.626 and 0.400, re-spectively) diameters of the hyperautofluorescent ring. center dot CONCLUSIONS: The significant correlations between FST and other clinical outcome measures highlight its potential as an adjunct outcome measure. (Am J Oph-thalmol 2023;245: 155-163. (c) 2022 Elsevier Inc. All rights reserved.)

Automated summary

The study showed significant correlations between FST threshold values and selected functional and anatomical outcome measures, particularly with LA 3.0 flicker amplitude and EZ band length measured on optical coherence tomography. This suggests the potential of FST as an adjunct outcome measure.